Short-term structured dietary and exercise interventions delay diabetes onset in prediabetic patients: a prospective quasi-experimental study.

Hypothesis: Prediabetes indicates an increased risk of developing diabetes mellitus. We hypothesized that structured anti-inflammatory and antioxidant dietary and exercise interventions (SAIDEs) can reduce the onset of diabetes in prediabetic patients. Methods: This study included 542 prediabetic patients who met at least one of the three common criteria for prediabetes: fasting blood glucose (FBG), 2-h oral glucose tolerance (2h OGTT), or hemoglobin A1c (HbA1C). Patients were randomly assigned to one of four groups using the block randomization method: routine community intervention, dietary intervention, exercise intervention, or SAIDEs for 6 months. Follow-up assessments were conducted at 6 months and 7.5 years, monitoring diabetes-related outcomes, inflammatory markers, and diabetes progression. Results: At baseline, most tested variables, including age, gender, body weight, blood lipids, blood sugar, β-cell function, blood inflammatory and immunological markers, and energy intake, did not differ among the groups. After 6 months of short-term interventions (diet, exercise, and SAIDEs) and 6 months of follow-up, all intervention groups exhibited reduced total energy intake, body weight, blood pressure, blood cholesterol, and glucose levels, along with improved β-cell functions (all Conclusions: Short-term intervention with SAIDEs exhibited significant anti-inflammatory activity and reduced the prevalence of abnormal blood glucose markers. These benefits persisted even after 6 months of follow-up. However, over the 8-year follow-up period, intensive SAIDEs did not reduce diabetes incidence among prediabetic patients but did delay its onset. Clinical trial registration: https://www.chictr.org.cn/searchproj.html, identifier ChiCTR-IOR-16008445.