Evidence map›Paper›PMID 40225421›Full record

ArticleAging brain2025

Effects of global

John Aaron Howell, Jonathan Larochelle, Rachel E Gunraj, Sofia M Stansbury, Lei Liu, Changjun Yang, Eduardo Candelario-Jalil

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging brain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

John Aaron HowellUniversity of Florida, Department of Neuroscience, United States.
Jonathan LarochelleUniversity of Florida, Department of Neuroscience, United States.
Rachel E GunrajUniversity of Florida, Department of Neuroscience, United States.
Sofia M StansburyUniversity of Florida, Department of Neuroscience, United States.
Lei LiuUniversity of Florida, Department of Neuroscience, United States.
Changjun YangUniversity of Florida, Department of Neuroscience, United States.
Eduardo Candelario-JalilUniversity of Florida, Department of Neuroscience, United States.

Funding

Multi-pronged Approach to Recalibrating the Inflammatory Cascade in Ischemic Stroke with BET blockadeR01NS109816 · NINDS · UNIVERSITY OF FLORIDA · PI CANDELARIO-JALIL, EDUARDO JESUS · 2019 to 2023
$1.9M
Role of RIPK2 in the neuroinflammatory response to ischemic strokeR01NS129136 · NINDS · UNIVERSITY OF FLORIDA · PI Eduardo Jesus Candelario-Jalil · 2023 to 2026
$1.6M
American Heart Association-American Stroke Association 971058NINDS NIH HHS R01 NS109816NINDS NIH HHS R01 NS129136
6 · The paper itself

Abstract

Besides the loss of blood and oxygen reaching the ischemic tissue, many secondary effects of ischemic stroke can cause additional tissue damage, including inflammation, oxidative stress, and proteomic disturbances. Receptor-interacting serine/threonine kinase 2 (RIPK2) is an important mediator in the post-stroke inflammatory cascade that responds to signals and molecular patterns released by dead or dying cells in the ischemic area. We hypothesize that RIPK2 signaling worsens injury and neurological recovery post-stroke and that global deletion of

Indexed as

AgingIschemic strokeMicrogliosisNeuroinflammationRIPK2

Identifiers

PMID40225421
PMCPMC11993155

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.