ArticleCureus2025
The Relationship Between Brain Frailty and Physical Function in Patients With Stroke Undergoing Rehabilitation.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Brain frailty has gained attention as a predictor of poor functional outcomes. However, the relationship between brain frailty and physical function among patients with stroke undergoing rehabilitation remains unclear. This study aimed to investigate the relationship between brain frailty and activities of daily living (ADLs) at discharge among patients with stroke admitted to a convalescent rehabilitation ward. Methods This single-center retrospective cohort study included patients with stroke admitted to the convalescent rehabilitation ward. Brain frailty (i.e., white matter hyperintensity, old vascular lesions, and brain atrophy) was evaluated using cranial magnetic resonance imaging at stroke onset. The outcome measure was defined as ADLs at discharge, assessed using the motor item of the Functional Independence Measure (FIM-M). Multiple regression and mediation analyses were performed to assess the association between brain frailty scores and FIM-M scores at discharge. Results The final analysis included 160 patients (median age: 73.0 years; interquartile range: 64.0-80.0 years; male: n = 90, 56.2%). The multiple regression analysis revealed that severe brain frailty (score of 3) was significantly associated with FIM-M scores at discharge, even after adjusting for covariates (β = -0.18; p = 0.041). Furthermore, mediation analysis revealed that severe brain frailty was associated with FIM-M scores at discharge through the mediation of cognitive function (total effect = -16.20; p < 0.001). Conclusions Brain frailty may provide new insights for outcome prediction in stroke rehabilitation, highlighting the importance of incorporating its assessment into routine clinical practice.
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