ArticleCureus2025
End-Expiratory Occlusion Test and Tidal Volume Challenge Test for Evaluating Fluid Responsiveness in Severe Traumatic Brain Injury, Septic Shock, and Acute Respiratory Distress Syndrome.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Resting-state functional MRI analysis of the brain's adaptation to chronic hypoxia: disease and environment.Quantitative imaging in medicine and surgery · 2026Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionFluid management in critically ill patients, particularly those with severe traumatic brain injury (TBI), septic shock, and acute respiratory distress syndrome (ARDS), presents a complex and multifaceted challenge. Dynamic tests such as the end-expiratory occlusion (EEO) test and tidal volume challenge (TVC) test are commonly used to assess fluid responsiveness, providing valuable insights into cardiovascular responses to changes in volume status. However, due to the unique risks and complications associated with these conditions, there is an increasing need to explore and evaluate alternative methods for predicting fluid responsiveness more safely and accurately in these critically ill patients.
methodsThis study presents a prospective investigation conducted on patients with severe TBI, septic shock, and ARDS. Before administering a 100 mL colloid bolus, both the EEO and TVC tests were performed. Initial measurements of cardiac output (CO), cardiac index (CI), and pulse pressure variation (PPV) were recorded, followed by subsequent measurements after each test to assess the fluid responsiveness and cardiovascular changes in these critically ill patients.
resultsAmong the 180 participants, a more than 5% increase in CI during the EEO test was indicative of fluid responsiveness. Similarly, a 3.5% absolute increase in PPV during the TVC test suggested fluid responsiveness. The interrater reliability for the EEO test was observed to be 0.915, indicating strong agreement between raters, while for PPV, it was 0.637, reflecting moderate agreement. These values suggest that the EEO test shows a high degree of consistency between different evaluators, whereas the PPV measurement demonstrates a more moderate level of reliability.
conclusionIn patients with severe TBI, septic shock, and ARDS who are receiving low tidal volume (VT) ventilation, both the EEO test for 15 seconds and the TVC method can be used to assess fluid responsiveness. However, it is important to note that the EEO test demonstrates greater reliability in this context.
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