Evidence map›Paper›PMID 40225581›Full record

ArticleTheranostics2025

Microglial Lcn2 knockout enhances chronic intracerebral hemorrhage recovery by restoring myelin and reducing inflammation.

Li Wang, Lei Zhang, Kai Wang, Jun He, Liang Yuan, Yangang Wang, Weihao Lv, Zehan Zhang, Yuan Feng, Hongchen Zhang and 5 more

Abstract read
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Down-regulation of lipocalin-2 alleviates depressive-like behaviors in mice through modulation of microglial activation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Li WangDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Lei ZhangDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Kai WangDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Jun HeZHANG Xi Provincial Famous Traditional Chinese Medicine Studio, Affiliated Hospital of Nanjing University of Chinese Medicine, Changzhou Hospital of Chinese Medicine, Changzhou, Jiangsu, 213003, China.
Liang YuanDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Yangang WangDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Weihao LvDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Zehan ZhangDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Yuan FengDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Hongchen ZhangDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Min ZhangDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Rui LvDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Ya-Nan DouDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Xiaowei FeiDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.
Jialiang WeiDepartment of Neurosurgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaanxi, 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cerebral HemorrhageInflammationLipocalin-2MicrogliaMyelin SheathAnimalsCell DifferentiationDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutOligodendrogliaSTAT3 Transcription FactorLcn2 protein, mouseLipocalin-2STAT3 Transcription FactorICHLcn2microgliamyelinOPCs

Identifiers

PMID40225581
PMCPMC11984404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.