Evidence map›Paper›PMID 40225588›Full record

ArticleTheranostics2025

LRG1 inhibition promotes acute pancreatitis recovery by inducing cholecystokinin Type 1 receptor expression via Akt.

Seok Ting Lim, Xinmei Zhao, Shuqing Liu, Wenjuan Zhang, Yuanyang Tan, Nidula Mullappilly, Sandip M Swain, Mei Ling Leong, Ravisankar Rajarethinam, Kah Fei Wan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Seok Ting LimCentre for Vision Research, Duke-NUS Medical School, Singapore.
Xinmei ZhaoGuangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou, China.
Shuqing LiuGuangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou, China.
Wenjuan ZhangGuangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou, China.
Yuanyang TanSchool of Medical Technology, Beijing Institute of Technology, 100081, Beijing, China.
Nidula MullappillyDepartment of Medicine, Duke University, Durham, NC, 27710, U.S.A.
Sandip M SwainDepartment of Medicine, Duke University, Durham, NC, 27710, U.S.A.
Mei Ling LeongSchool of Biological Sciences, Nanyang Technological University, Singapore.
Ravisankar RajarethinamAdvanced Molecular Pathology Laboratory (AMPL), Institute of Molecular and Cell Biology, A*STAR, Singapore.
Kah Fei WanAntibody Technology Division, Experimental Drug Development Centre, A*STAR, Singapore.
Christiane RuedlSchool of Biological Sciences, Nanyang Technological University, Singapore.
Rodger A LiddleDepartment of Medicine, Duke University, Durham, NC, 27710, U.S.A.
Liang LiDepartment of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology.
Xiaomeng WangCentre for Vision Research, Duke-NUS Medical School, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

GlycoproteinsPancreatitisProto-Oncogene Proteins c-aktReceptors, CholecystokininAcinar CellsAnimalsCeruletideDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutPancreasCeruletideGlycoproteinsLRG1 protein, humanLRG1 protein, mouseProto-Oncogene Proteins c-aktReceptors, CholecystokininAcute pancreatitisCholecystokinin Type 1 receptorLeucine-rich alpha-2 glycoprotein 1Pancreatic regenerationTransforming-growth factor-beta

Identifiers

PMID40225588
PMCPMC11984386

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.