Evidence map›Paper›PMID 40225907›Full record

ArticlePPAR research2025

Single and Multiple Doses of Seladelpar Decrease Diurnal Markers of Bile Acid Synthesis in Mice.

Edward E Cable, Jeffrey W Stebbins, Jeff D Johnson, Yun-Jung Choi, Jiangao Song, Sole Gatto, Matthew Onorato, Charles A McWherter

Abstract read
In one paragraph

Article in PPAR research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Edward E CableCymaBay Therapeutics Inc., Fremont, California, USA.ORCID https://orcid.org/0000-0002-9268-968X
Jeffrey W StebbinsCymaBay Therapeutics Inc., Fremont, California, USA.
Jeff D JohnsonCymaBay Therapeutics Inc., Fremont, California, USA.ORCID https://orcid.org/0009-0001-9384-9577
Yun-Jung ChoiCymaBay Therapeutics Inc., Fremont, California, USA.ORCID https://orcid.org/0000-0002-5153-9714
Jiangao SongCymaBay Therapeutics Inc., Fremont, California, USA.ORCID https://orcid.org/0000-0002-7798-8868
Sole GattoMonoceros Biosystems LLC, San Diego, California, USA.ORCID https://orcid.org/0000-0003-3479-418X
Matthew OnoratoMonoceros Biosystems LLC, San Diego, California, USA.
Charles A McWherterCymaBay Therapeutics Inc., Fremont, California, USA.ORCID https://orcid.org/0000-0002-7613-3008

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peroxisome proliferator-activated receptors (PPARs) modulate bile metabolism and are important therapeutic options in cholestatic diseases. This study was aimed at understanding the effects of single and multiple doses of seladelpar, a PPAR

Indexed as

bile metabolismcircadian rhythmPPARPPAR deltaseladelpar

Identifiers

PMID40225907
PMCPMC11991775

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.