ArticleAmerican journal of translational research2025
Causal relationship between hand grip strength and cognition/dementia risk: a Mendelian randomization study.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Predicting the onset of dementia with longitudinal performance-based measures of physical function.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundMuscle strength positively correlates with cognitive function, with the bidirectional causal link between hand grip strength and cognition posing a significant but incompletely understood public health challenge. This study aimed to explore the causal relationship between hand grip strength and cognition and its effect on dementia.
methodsA two-sample Mendelian randomization analysis used genome-wide significant single nucleotide polymorphisms (SNPs) (P < 5×10
resultsThe inverse variance weighted (IVW) analysis indicated a directional positive causal effects of hand grip strength on cognition (Left-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.026)/performance (OR (95% Cl): 1.16 (1.04-1.30), P = 0.009); Right-hand grip strength on cognitive function (OR (95% Cl): 1.23 (1.02-1.48), P = 0.031)/performance (OR (95% Cl): 1.10 (1.02-1.19), P = 0.018), with almost no reverse causality between cognitive function/performance and hand grip strength. Based on the results above, we then researched the directional causal effects of hand grip strength on neurodegenerative diseases (like dementia) with cognitive decline as the main clinical manifestation. However, the IVW methods yielded no evidence to support a causal effect of left-hand grip strength on dementia (P > 0.05).
conclusionsThis MR study indicates a positive directional causal relationship between hand grip strength and cognition, with no observed causal link to dementia. These results hold implications for the development of public health measures and strategies for preventing cognitive decline.
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