SynthesisDepression and anxiety2024
Prevalence and Predictors of Nonresponse to Psychological Treatment for PTSD: A Meta-Analysis.
Synthesis in Depression and anxiety, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Do subjective and objective baseline sleep disturbances predict post-traumatic stress disorder treatment response? A secondary analysis of a randomized controlled trial.European journal of psychotraumatology · 2026Trial
- Unfinished business: A grounded theory analysis of change among individuals classified as numerical non-responders to psychodynamic psychotherapy for post-traumatic stress disorder related to childhood maltreatment.Psychology and psychotherapy · 2026Trial
- Randomized Clinical Trial of Imagery Stabilization and Rescripting Therapy for Psychiatric Outpatients with Posttraumatic Stress Disorder.Yonsei medical journal · 2026Trial
- Treatment of posttraumatic stress disorder (PTSD).Dialogues in clinical neuroscience · 2026Review
- Psychotherapy for PTSD - a scoping review of how change during treatment has been studied.European journal of psychotraumatology · 2026Article
- Augmenting virtual reality exposure for PTSD with physical activity: study protocol of a randomised controlled trial.European journal of psychotraumatology · 2026Article
- The microbiome and PTSD: a scoping review across preclinical and clinical studies.European journal of psychotraumatology · 2026Article
- Deepfake perpetrator conversation for adults with sexual abuse-related posttraumatic stress disorder: intervention development and multiple baseline study protocol.European journal of psychotraumatology · 2026Article
- The efficacy of EMDR therapy in adults with a severe intellectual disability and posttraumatic stress disorder.European journal of psychotraumatology · 2026Article
- At-Home Telehealth-Supported Subcutaneous Ketamine Therapy for Safety, Feasibility, and Clinical Outcomes in Adults With Moderate to Severe Depression, Anxiety, or Posttraumatic Stress Disorder in a Large, Heterogeneous Cohort in the United States: Retrospective Cohort Study.Journal of medical Internet research · 2026Article
- The long road to routine care: piloting the digital mental health intervention for PTSD "Radius Grow" in a psychiatric residential setting.BMC psychology · 2026Article
- A repeated low-dose regimen of MDMA has transient next-day effects on locomotor activity, anxiety-like behavior, and brain serotonin levels, with no effect on anhedonia-like behavior, in both female and male rats.Psychopharmacology · 2026Article
- The Silexan in the Treatment Of Posttraumatic stress disorder (STOP) trial: protocol for a 12-week randomised controlled trial of adjunctive Silexan for PTSD.BMC complementary medicine and therapies · 2026Article
- Ketogenic metabolic therapy for treatment-resistant post-traumatic stress disorder (PTSD): a retrospective case report.Frontiers in nutrition · 2026Article
- A non-trauma-focused equine-assisted intervention was associated with reductions in all four PTSD symptom clusters in treatment-resistant military veterans.Frontiers in psychology · 2026Article
- Body-based therapies and transcranial magnetic stimulation for posttraumatic stress disorder: a proposed integrative approach.Frontiers in psychiatry · 2026Review
- Biological mechanisms underlying adverse mental health outcome after trauma.European journal of psychotraumatology · 2025Article
- Can therapists and senior advisors predict improvement of PTSD severity, based on clinical intuition and liking of their patients?European journal of psychotraumatology · 2025Article
- Cognitive processing therapy for posttraumatic stress disorder in first responders and veterans: Flexing the approach with explicit case formulation.Journal of traumatic stress · 2025Article
- Are specific PTSD criteria associated with treatment outcome in traumatized veterans and police officers?European journal of psychotraumatology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Although highly efficacious psychological treatments for posttraumatic stress disorder (PTSD) exist, there is evidence that first-line psychological treatment approaches leave a substantial subgroup of patients still suffering from clinically relevant PTSD symptoms posttreatment. Aims: We aimed to meta-analytically establish the prevalence and predictors of nonresponse to first-line guideline-recommended psychological treatments for PTSD. Materials and Methods: This meta-analysis was preregistered (CRD42023368766). We searched the PTSD Trials Standardized Data Repository, Embase, Medline, PsychINFO, and PTSDpubs. We included randomized controlled trials (RCT), reporting data on nonresponse operationalized by (lack of) symptom reduction in PTSD symptoms at posttreatment of first-line guideline-recommended PTSD treatments for adult patients meeting criteria for a PTSD diagnosis. All studies published by October 10, 2023, were included. Data were extracted by two independent reviewers. We estimated the pooled average nonresponse rates and ORs. Subgroup and metaregression analyses targeting the nonresponse rates served to identify significant predictors. All analyses were conducted using three-level multilevel models. Study quality was assessed using Cochrane's RoB 2 tool. Results: Eighty six studies with 117 active treatment conditions and 7,894 participants were included in the meta-analysis. The weighted average nonresponse rate was 39.23%, 95% CI (35.08%, 43.53%). Nonresponse was less frequent in the treatment condition compared to the control condition ( Conclusions: This meta-analysis found that a substantial subgroup of patients suffering from PTSD still showed clinically significant symptoms after having received treatment. Treatment modifications should be considered for specific subgroups of PTSD patients based on predictors found to be associated with nonresponse.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.