ArticleNaunyn-Schmiedeberg's archives of pharmacology2025
Quercetin loaded-magnetic zeolite nano-composite material and evaluate its anti-cancer effect.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Novel Organomineral Complex with Prolonged Antitumor Action.International journal of molecular sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quercetin (QUR) is a major flavonoid that is abundantly present in the human diet, and has various therapeutic effects, including anti-cancer and anti-inflammatory properties. Of note, high doses of free QUR can be dangerous to normal cells. Furthermore, a considerable amount of free QUR would be metabolized until reaching cancerous cells. On one hand, chemotherapy drugs have some side effects towards normal cells. Besides, nano zeolite clinoptilolite (NZ-CP), a drug delivery system (DDS), has high specific surface area and is non-toxic. By applying magnetic zeolite nano-composite (MZNC), purposeful mobility of high doses of QUR, considering acidic microenvironment of tumor, is possible. The aim of this work is to evaluate and compare the anti-cancer impacts of QUR-loaded MZNC with doxorubicin (DOX) as an anti-cancer drug on HepG2 cell line as a human cancer cell line. Various concentrations of NZ-CP at different times to evaluate its safety in normal cells were assessed. Also, to assess the cell survival of the HepG2 cell line, various amounts of QUR-loaded MZNC, DOX, and NZ-CP within cell viability assay were investigated. Based on results of normal cells assay, it was revealed that NZ-CP has no toxicity toward normal cells. Furthermore, according to evaluations of cell viability assay, it was determined that specific concentrations (100 and 200 mg/L) of QUR have a similar anti-cancer effect to DOX. Eventually, it was exhibited that NZ-CP has capability of controlled QUR release until reaching cancerous cells demonstrating its aptitude for drug delivery.
Indexed as
Identifiers
40227305What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.