Evidence map›Paper›PMID 40227307›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Lipoic acid as a protective agent against lipopolysaccharide and other natural toxins: a comprehensive review.

Seyedeh Farzaneh Omidkhoda, Fatemeh Rajabian, Hossein Hosseinzadeh

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Seyedeh Farzaneh OmidkhodaPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Fatemeh RajabianDepartment of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Hossein HosseinzadehPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. hosseinzadehh@mums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alpha-lipoic acid, also known as lipoate or lipoic acid (LA), is naturally present in the mitochondria of cells, where it functions as a cofactor for dehydrogenase enzyme complexes. It has also been reported that LA is a potent antioxidant. Not only does it scavenge free radicals directly, but it can also regenerate other essential cellular antioxidants. LA exhibits various anti-inflammatory effects and offers protection to mitochondria. Numerous studies have assessed the potential protective effects of LA against natural toxins, including lipopolysaccharides, galactosamine, mycotoxins, snake venoms, and toxins derived from cyanobacteria and plants. In general, the results of these studies indicate that LA can be effective in mitigating various toxicities, primarily due to the previously mentioned capabilities. Furthermore, novel mechanisms have been proposed for LA against specific toxins, for example, direct inactivation of secretory phospholipase A

Indexed as

AntioxidantsLipopolysaccharidesProtective AgentsThioctic AcidToxins, BiologicalAnimalsHumansAntioxidantsLipopolysaccharidesProtective AgentsThioctic AcidToxins, BiologicalLipoic acidLipopolysaccharideNatural toxinThioctic acidToxicity

Identifiers

PMID40227307

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.