Evidence map›Paper›PMID 40227649›Full record

ArticleCancers2025

Combined Omipalisib and MAPK Inhibition Suppress PDAC Growth.

Bailey A Bye, Jarrid L Jack, Alexandra Pierce, Richard McKinnon Walsh, Austin E Eades, Prabhakar Chalise, Appolinaire Olou, Michael N VanSaun

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. KRAS Inhibition in Pancreatic Ductal Adenocarcinoma.Journal of clinical medicine · 2026
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Bailey A ByeDepartment of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.ORCID 0000-0002-7278-3927
Jarrid L JackDepartment of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
Alexandra PierceDepartment of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
Richard McKinnon WalshDepartment of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.ORCID 0000-0003-2338-3115
Austin E EadesDepartment of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
Prabhakar ChaliseDepartment of Biostatistics and Data Science, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.ORCID 0000-0001-5581-1220
Appolinaire OlouDepartment of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.
Michael N VanSaunDepartment of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA.ORCID 0000-0002-2538-8107

Funding

Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI ROY A. JENSEN · 2012 to 2026
$40.1M
Novel Approaches for the Control of Microbial PathogensP30GM103326 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI LUTKENHAUS, JOSEPH F · 2012 to 2016
$5.3M
Counteracting molecular mechanisms of obesity dependent PDAC progressionR01CA231052 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI VANSAUN, MICHAEL NATHAN · 2019 to 2023
$1.7M
Investigating the role of SHP2-PLCG1 interaction in PDAC calcium signaling and metabolismF31CA281118 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI WALSH, RICHARD MCKINNON · 2023 to 2024
$72k
National Institute of Health, National Cancer Institute CA231051, CA281118, CA168524, GM103326NCI NIH HHS F31 CA281118NCI NIH HHS P30 CA168524NCI NIH HHS R01 CA231052NIGMS NIH HHS P30 GM103326
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

inhibitorsMAPKpancreaspancreatic cancerPDACPI3KSHP2targeted therapytherapeutics

Identifiers

PMID40227649
PMCPMC11987824

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.