Evidence map›Paper›PMID 40228052›Full record

ArticleMagnetic resonance in medicine2025

Age dependency of neurometabolite T

Saipavitra Murali-Manohar, Helge J Zöllner, Kathleen E Hupfeld, Yulu Song, Emily E Carter, Vivek Yedavalli, Steve C N Hui, Dunja Simicic, Aaron T Gudmundson, Gizeaddis Lamesgin Simegn and 4 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Saipavitra Murali-ManoharRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4978-0736
Helge J ZöllnerRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7148-292X
Kathleen E HupfeldRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yulu SongRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Emily E CarterDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.
Vivek YedavalliRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Steve C N HuiDeveloping Brain Institute, Children's National Hospital, Washington, DC, USA.ORCID 0000-0002-1523-4040
Dunja SimicicRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-6600-2696
Aaron T GudmundsonRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0001-5104-0959
Gizeaddis Lamesgin SimegnRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Christopher W Davies-JenkinsRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3083-9811
Eric C PorgesDepartment of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0671-7374

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Peter CM Van Zijl · 2021 to 2026
$9.9M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Edited Magnetic Resonance Spectroscopy of the Pediatric BrainR01EB032788 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2023 to 2026
$2.7M
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
General Linear Modeling For Magnetic Resonance SpectroscopyR21EB033516 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2022 to 2024
$670k
Cortical Inhibition and Mobility in Older AdultsK00AG068440 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUPFELD, KATHLEEN ELIZABETH · 2022 to 2024
$222k
Brain metabolism across the lifespan using multi-parametric MRSK99AG080084 · NIA · JOHNS HOPKINS UNIVERSITY · PI ZOELLNER, HELGE JOERN · 2023 to 2024
$212k
NIA NIH HHS K00 AG068440NIA NIH HHS K99 AG080084NIA NIH HHS R00 AG062230NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIBIB NIH HHS R01 EB032788NIBIB NIH HHS R21 EB033516NICHD NIH HHS P50 HD103538NIH HHS K00 AG068440NIH HHS K99 AG080084NIH HHS P41 EB031771NIH HHS R00 AG062230NIH HHS R01 EB016089NIH HHS R01 EB023963NIH HHS R21 EB033516
6 · The paper itself

Abstract

purposeTo measure T

methodsA cohort of 101 healthy adults was recruited with approximately 10 male and 10 female participants in each "decade" band: 18 to 29, 30 to 39, 40 to 49, 50 to 59, and 60+ years old. Inversion-recovery PRESS data (TE/TR: 30/2000 ms) were acquired at 8 inversion times (TIs) (300, 400, 511, 637, 780, 947, 1148, and 1400 ms) from voxels in white-matter-rich centrum semiovale (CSO) and gray-matter-rich posterior cingulate cortex (PCC). Modeling of TI-series spectra was performed in Osprey 2.5.0. Quantified metabolite amplitudes for total N-acetylaspartate (tNAA

resultsT

conclusionMetabolite T

Indexed as

AgingBrainMagnetic Resonance ImagingAdolescentAdultAgedAspartic AcidCholineCreatineFemaleHumansMagnetic Resonance SpectroscopyMaleMiddle AgedYoung AdultAspartic AcidCholineCreatineN-acetylaspartatehealthy aginginversion recoverymagnetic resonance spectroscopymetabolitesT1 relaxation times

Identifiers

PMID40228052
PMCPMC12670978

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.