Evidence map›Paper›PMID 40228688›Full record

ArticleThe journal of pain2025

Beyond pain intensity: Validating single-item pain bothersomeness measures.

Karlyn A Edwards, Dokyoung Sophia You, Edward W Lannon, Troy C Dildine, Beth D Darnall, Sean C Mackey

Abstract readValidation Study
In one paragraph

Article in The journal of pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Karlyn A EdwardsDivision of Pain Medicine, Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA; Division of General Internal Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: kae132@pitt.edu.
Dokyoung Sophia YouDivision of Pain Medicine, Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Edward W LannonDivision of Pain Medicine, Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Troy C DildineDivision of Pain Medicine, Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Beth D DarnallDivision of Pain Medicine, Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.
Sean C MackeyDivision of Pain Medicine, Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, CA, USA.

Funding

Prognostic biomarkers for high-impact chronic pain: Development and validationR61NS118651 · NINDS · STANFORD UNIVERSITY · PI MACKEY, SEAN C · 2020 to 2020
$7.3M
Interdisciplinary Research Training in Pain and Substance Use DisordersT32DA035165 · NIDA · STANFORD UNIVERSITY · PI SEAN C MACKEY · 2013 to 2026
$7.2M
University of Pittsburgh Collaboration in Addiction Training Scholars (PittCATS) ProgramK12DA050607 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Jane M. Liebschutz, Erin L Winstanley · 2020 to 2026
$3.2M
Research and Mentoring in Innovative Patient Oriented Pain and Opioid ScienceK24DA053564 · NIDA · STANFORD UNIVERSITY · PI Beth Denise Darnall · 2021 to 2026
$1.0M
Effect of pain catastrophizing on prescription opioid cravingK23DA048972 · NIDA · STANFORD UNIVERSITY · PI YOU, DOKYOUNG SOPHIA · 2019 to 2023
$758k
Characterization of Longitudinal EEG Biomarkers in Chronic Low Back PainK23AR083171 · NIAMS · STANFORD UNIVERSITY · PI Edward W. Lannon · 2023 to 2026
$468k
Mentoring in Discovery and Validation of Clinical Chronic Pain BiomarkersK24NS126781 · NINDS · STANFORD UNIVERSITY · PI MACKEY, SEAN C · 2021 to 2021
$324k
NIAMS NIH HHS K23 AR083171NIDA NIH HHS K12 DA050607NIDA NIH HHS K23 DA048972NIDA NIH HHS K24 DA053564NIDA NIH HHS T32 DA035165NINDS NIH HHS K24 NS126781NINDS NIH HHS L30 NS124021NINDS NIH HHS R61 NS118651
6 · The paper itself

Abstract

Chronic pain is a complex and multifaceted health condition, rendering pain intensity alone insufficient for comprehensively understanding the impact of pain. Pain bothersomeness scales have been developed to measure pain's impact on life, however lack adequate validation. Our study examines the validity of two single-item measures (5-point and 11-point response scales) for pain bothersomeness. We collected data from 633 treatment-seeking adults with mixed-etiology chronic pain. Pearson correlations were conducted to examine the relationships between each pain bothersomeness item and 20 general and pain-related functioning measures. ANOVAs examined the ability of pain bothersomeness scores to discriminate between eight groupings based on general and pain-related functioning. Linear regressions analyzed pain bothersomeness as a predictor of 14 measures of general and pain-related functioning three months later. Both pain bothersomeness items correlated significantly with 19 functioning measures and discriminated between eight groupings. Controlling for covariates, both items were consistently predictive of worse pain interference (Total adj r² =.34), pain catastrophizing (Total adj r² =.21-.22), depression (Total adj r² =.25-.26), and satisfaction with social roles (Total adj r² =.13-.16) three months later. Both single-item pain bothersomeness items demonstrated consistent concurrent, discriminant, and predictive validity. These low-burden assessments provide valuable information about patient functioning in clinical settings, suggesting their utility in improving chronic pain care. PERSPECTIVE: Both single-item pain bothersomeness measures demonstrated consistent concurrent and discriminant validity. Both items predicted worse pain interference, pain catastrophizing, depression, and social functioning 3-months later.

Indexed as

CatastrophizationChronic PainPain MeasurementAdultAgedDepressionFemaleHumansMaleMiddle AgedPsychometricsReproducibility of ResultsYoung AdultChronic painMental healthPain bothersomenessPain interferenceValidity

Identifiers

PMID40228688
PMCPMC12603663

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.