Evidence map›Paper›PMID 40228797›Full record

ArticleACS applied materials & interfaces2025

Combating Concomitant Bacterial and Fungal Infections via Codelivery of Nitric Oxide and Fluconazole.

Rashmi Pandey, Natalie Crutchfield, Mark Richard Stephen Garren, Ekaa Manohar Kasetty, Manjyot Kaur Chug, Elizabeth J Brisbois, Hitesh Handa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rashmi PandeySchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-8129-7528
Natalie CrutchfieldSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.
Mark Richard Stephen GarrenSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-5194-6558
Ekaa Manohar KasettyFranklin College of Arts and Sciences, University of Georgia, Athens, Georgia 30602, United States.
Manjyot Kaur ChugSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0001-8194-4481
Elizabeth J BrisboisSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-9283-5448
Hitesh HandaSchool of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.ORCID 0000-0002-9369-7374

Funding

Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applicationsR01HL134899 · NHLBI · UNIVERSITY OF GEORGIA · PI HANDA, HITESH · 2017 to 2025
$3.0M
Nitric Oxide Functionalized Antibiotics to Combat Infections and Thrombosis for Extracorporeal Life SupportR01HL172496 · NHLBI · UNIVERSITY OF GEORGIA · PI Elizabeth Joy Brisbois, Hitesh Handa · 2024 to 2026
$1.5M
NHLBI NIH HHS R01 HL134899NHLBI NIH HHS R01 HL172496
6 · The paper itself

Abstract

Device-associated infections are a major challenge for healthcare and cause patient morbidity and mortality as well as pose a significant economic burden. Infection-causing bacteria and fungi are equally notorious and responsible for biofilm formation and the development of antibiotic and antifungal-resistant strains. Biomaterials resisting bacterial and fungal adhesion can address device-associated infections more safely and efficiently than conventional systemic antibiotic therapies. Herein, we present a combination of potent antibacterial nitric oxide (NO) with antifungal fluconazole codelivery system from a polymeric matrix to combat bacterial and fungal infections simultaneously. The NO donor

Indexed as

Anti-Bacterial AgentsAntifungal AgentsFluconazoleNitric OxideAnimalsBiofilmsCandida albicansEscherichia coliMiceMicrobial Sensitivity TestsPolyurethanesS-Nitroso-N-AcetylpenicillamineStaphylococcus aureusAnti-Bacterial AgentsAntifungal AgentsFluconazoleNitric OxidePolyurethanesS-Nitroso-N-Acetylpenicillamineantibacterialantifungaldrug deliveryfluconazolehospital-acquired infectionsnitric oxide

Identifiers

PMID40228797
PMCPMC12022954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.