Evidence map›Paper›PMID 40229850›Full record

ArticleEuropean journal of medical research2025

Associations of serum uric acid, risk of atherosclerotic cardiovascular disease, and mortality: results from NHANES.

Rundong Chen, Miao Pang, Yilei Zhang, Hongjian Zhang, Guanghao Zhang, Yutian Wei, Weilong Hua, Xiaoxi Zhang, Lei Zhang, Zifu Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rundong Chen *School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Miao Pang *Neurovascular Center, Changhai Hospital, Naval Medical University, #168 Changhai Road, Shanghai, 200433, China.
Yilei Zhang *Nursing Department, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China.
Hongjian ZhangSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Guanghao ZhangNeurovascular Center, Changhai Hospital, Naval Medical University, #168 Changhai Road, Shanghai, 200433, China.
Yutian WeiNeurovascular Center, Changhai Hospital, Naval Medical University, #168 Changhai Road, Shanghai, 200433, China.
Weilong HuaNeurovascular Center, Changhai Hospital, Naval Medical University, #168 Changhai Road, Shanghai, 200433, China.
Xiaoxi ZhangNeurovascular Center, Changhai Hospital, Naval Medical University, #168 Changhai Road, Shanghai, 200433, China.
Lei ZhangNeurovascular Center, Changhai Hospital, Naval Medical University, #168 Changhai Road, Shanghai, 200433, China.
Zifu LiNeurovascular Center, Changhai Hospital, Naval Medical University, #168 Changhai Road, Shanghai, 200433, China.
Qiang LiNeurovascular Center, Changhai Hospital, Naval Medical University, #168 Changhai Road, Shanghai, 200433, China.
Pengfei YangSchool of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China. p.yang@vip.163.com.

Funding

National Ten Thousand Talents Plan Young Top-notch Talent Support Program SQ2022QB00715Shanghai Science and Technology Commission Science and Technology Innovation Action Plan 24SF1902500
6 · The paper itself

Abstract

backgroundAtherosclerotic cardiovascular disease (ASCVD) has long been recognized as a significant contributor to mortality rates, holding a prominent position in the hierarchy of causes of death. Nevertheless, the presence of a causal relationship between serum uric acid (SUA) and the risk of ASCVD, as well as mortality rates, remains unclear.

methodsWe initially conducted a comprehensive cohort study utilizing data sourced from National Health and Nutrition Examination Survey (NHANES) 1999-2018 to investigate the specific correlation between SUA levels and ASCVD. Then, we subsequently examined the link between SUA levels and all-cause and cardio-cerebrovascular mortality among ASCVD individuals.

resultsWe identified a U-shaped relationship between SUA levels and the risk of ASCVD in all participants (inflection point at 5.399, p value = 0.014). Similarly, SUA levels showed U-shaped trends with all-cause mortality (inflection point at 5.748, p value < 0.0001) and cardio-cerebrovascular mortality (inflection point at 5.936, p value < 0.0001), respectively.

conclusionsOur findings demonstrate a U-shaped association between SUA levels and the risks of ASCVD, all-cause mortality, and cardio-cerebrovascular mortality. However, further research is needed to better understand how SUA affects ASCVD and its underlying mechanisms.

Indexed as

AtherosclerosisCardiovascular DiseasesUric AcidAdultAgedBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedNutrition SurveysRisk FactorsUnited StatesBiomarkersUric AcidAtherosclerotic cardiovascular diseaseMortalityNHANESSerum uric acid

Identifiers

PMID40229850
PMCPMC11998467

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.