Evidence map›Paper›PMID 40230302›Full record

ArticlePsychological medicine2025

Sleep and schizophrenia polygenic scores in non-affective and affective psychotic disorders.

Erik Cederlöf, Minna Holm, Anders Kämpe, Ari Ahola-Olli, Katri Kantojärvi, Markku Lähteenvuo, Johan Ahti, Jarmo Hietala, Katja Häkkinen, Erkki Isometsä and 11 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Erik CederlöfFinnish Institute for Health and Welfare, Helsinki, Finland.ORCID 0000-0003-2911-1794
Minna HolmFinnish Institute for Health and Welfare, Helsinki, Finland.
Anders KämpeInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Ari Ahola-OlliInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Katri KantojärviFinnish Institute for Health and Welfare, Helsinki, Finland.
Markku LähteenvuoNiuvanniemi Hospital, University of Eastern, Kuopio, Finland.
Johan AhtiDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jarmo HietalaFaculty of Medicine, University of Turku, Turku, Finland.
Katja HäkkinenNiuvanniemi Hospital, University of Eastern, Kuopio, Finland.
Erkki IsometsäDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Annamari Tuulio-HenrikssonDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Olli KampmanFaculty of Medicine, University of Turku, Turku, Finland.
Kaisla LahdensuoDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jouko LönnqvistFinnish Institute for Health and Welfare, Helsinki, Finland.
Jari TiihonenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Hannu TurunenFinnish Institute for Health and Welfare, Helsinki, Finland.
Asko WegeliusDepartment of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Juha VeijolaDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Tuula KieseppäFinnish Ministry of Social Affairs and Health, Helsinki, Finland.
Aarno PalotieInstitute for Molecular Medicine FIMM, University of Helsinki, Helsinki, Finland.
Tiina PaunioFinnish Institute for Health and Welfare, Helsinki, Finland.

Funding

Academy of Finland 357643Finska Läkaresällskapet 8-1353-9Helsingin ja Uudenmaan Sairaanhoitopiiri TYH2021328Svenska Sällskapet för Medicinsk Forskning PD20-0190
6 · The paper itself

Abstract

backgroundSleep problems are common in psychotic disorders and are associated with worse quality of life and disease prognosis. Genome-wide association studies (GWAS) have revealed genetic influences for schizophrenia and sleep, but polygenic scores (PGSs) for sleep traits have not been evaluated systematically in patients with psychotic disorders.

methodsThis study investigated the associations between PGSs for sleep traits (insomnia, PGS

resultsPGS

conclusionGenetic risks for sleep and diurnal preference vary between non-affective psychosis, affective psychosis, and the general population. The findings in this study emphasize the heterogeneity in genetic etiology of the objective features of disease severity and the more subjective measures related to well-being and self-reported measures of sleep.

Indexed as

Bipolar DisorderMultifactorial InheritancePsychotic DisordersSchizophreniaSleepSleep Wake DisordersAdultFemaleFinlandGenome-Wide Association StudyHumansMaleMiddle AgedQuality of Lifecognitionpolygenic scorespsychotic disordersschizophreniasleep

Identifiers

PMID40230302
PMCPMC12094621

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.