ArticleFrontiers in aging neuroscience2025
Allostatic load, a measure of cumulative physiological stress, impairs brain structure but not
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Multidimensional Physiological and Gut Microbiome Profiling Identifies Subtle Physiological Patterns in an Apparently Healthy Aging Indian Cohort: A Cross-Sectional Observational Study.Microorganisms · 2026Article
- Association Between Multidimensional Housing Precarity and Cognitive Function Among Older Adults: Findings from the National Survey of Older Koreans, 2023.Journal of general internal medicine · 2026Article
- Contextualizing Blood-Based Biomarkers for Dementia Globally.Journal of neurochemistry · 2026Review
- Hierarchical-circular model of biological memory: a multilevel hypothesis for pathogenesis and allostatic integrity in Alzheimer's disease and related dementias.Frontiers in dementia · 2026Article
- Associations among structural brain alterations, respiratory symptoms and cognitive impairment in patients with chronic obstructive pulmonary disease-related subclinical cognitive vulnerability: a multimodal neuroimaging study.Frontiers in aging neuroscience · 2026Article
- Physical activity attenuates the association between allostatic load and early Alzheimer's disease-related biomarkers in older adults.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
18 authors.
Funding
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Abstract
Introduction: Allostatic load (AL) is a composite score of progressive physiological dysregulations in response to long-term exposure to everyday stress. Despite growing interest, limited research has focused on links with cerebral and cognitive aspects of aging and with markers sensitive to Alzheimer's disease (AD) in a healthy elderly population and with a multimodal approach. Methods: At baseline, 111 older adults (without cognitive impairment) from the Age-Well trial completed blood and anthropometric markers collection, cognitive assessments and multimodal neuroimaging within 3 months. Results: AL was negatively associated with gray matter volume and white matter integrity within frontal and temporal regions and poorer attentional performance. Discussion: AL is linked to structural brain integrity in aging- and stress-sensitive regions but not with AD-related markers (
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Registered trials
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