Evidence mapPaperPMID 40231176Full record

Observational studyFrontiers in public health2025

The sepsis journey and where digital alerts can help: a qualitative, interview study with survivors and family members in England.

Runa Lazzarino, Aleksandra J Borek, Andrew J Brent, John Welch, Kate Honeyford, Ron Daniels, Anne Kinderlerer, Graham Cooke, Shashank Patil, Anthony Gordon and 5 more

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05741801 (Digital Alerting to Improve Sepsis Detection and Patient Outcomes in NHS Trusts. A Qualitative Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05741801 completednot on this map

Digital Alerting to Improve Sepsis Detection and Patient Outcomes in NHS Trusts. A Qualitative Study (DiAlS Qual).

TypeobservationalSponsorUniversity of OxfordRan2022 to 2023Enrolled39ConditionsSepsisArmsinterviews
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Runa LazzarinoNuffield Department of Primary Care Health Sciences, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Aleksandra J BorekNuffield Department of Primary Care Health Sciences, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
Andrew J BrentOxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
John WelchUniversity College London Hospitals NHS Foundation Trust, London, United Kingdom.
Kate HoneyfordTeam Health Informatics, Institute of Cancer Research, London, United Kingdom.
Ron DanielsUK Sepsis Trust and Global Sepsis Alliance, Birmingham, United Kingdom.
Anne KinderlererImperial College Healthcare NHS Trust, London, United Kingdom.
Graham CookeImperial College Healthcare NHS Trust, London, United Kingdom.
Shashank PatilChelsea and Westminster Hospital, London, United Kingdom.
Anthony GordonUniversity Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
Philippa GoodmanPPI Representative, Oxford, United Kingdom.
Ben GlampsonImperial College Healthcare NHS Trust, London, United Kingdom.
Peter GhazalSchool of Medicine, Cardiff University, Cardiff, United Kingdom.
Ceire CostelloeTeam Health Informatics, Institute of Cancer Research, London, United Kingdom.
Sarah Tonkin-CrineNuffield Department of Primary Care Health Sciences, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The fight against sepsis is an ongoing healthcare challenge, where digital tools are increasingly used with some promising results. The experience of survivors and their family members can help optimize digital alerts for sepsis/deterioration. This study pairs the experiences of survivors of their sepsis journey and family members with their knowledge and views on the role of digital alerts. Methods: A qualitative study with online, semi-structured interviews and focus groups with sepsis survivors and family members in England. Data were analyzed inductively using thematic analysis. Results: We included 11 survivors, and 5 family members recruited via sepsis charities and other social media, for a total of 15 sepsis cases. Identified categories correspond to the three stages of the sepsis journey: 1. Pre-hospital, onset symptoms and help-seeking; 2. Hospital admission and stay; 3. Post-sepsis syndrome. The role of digital alerts at each stage of the sepsis journey is discussed. Participants' experiences were varied, previous sepsis awareness scant, and knowledge of digital alerts minimal. However, participants were confident in the potential of alerts contributing along the sepsis journey. They perceived digital alerts as important in healthcare professionals' decision-making to expedite identification and treatment of sepsis and suggested their expansion across healthcare services. Participants expressed that awareness should be increased among the general public about digital alerts for sepsis/deterioration. Discussion: In light of sepsis' insidious and variable manifestation, the involvement of patients and family members in the development of digital alerts is crucial to optimize their design and deployment towards improving outcomes. Digital alerts should enhance the connection across healthcare services as well as the care quality. They should also enhance the communication between patients and healthcare professionals. Clinical trial registration: The ClinicalTrials.gov registration identifier for this study is NCT05741801; the protocol ID is 16347.

Indexed as

FamilySepsisSurvivorsAdultAgedAged, 80 and overEnglandFemaleFocus GroupsHumansInterviews as TopicMaleMiddle AgedQualitative Researchdigital alertsEnglandfamily memberssecondary emergency caresepsis survivors

Identifiers

PMID40231176
PMCPMC11995637

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.