Evidence mapPaperPMID 40231496Full record

ReviewCurrent protein & peptide science2025

Decoding the Molecular Mechanisms of miRNAs: Protein Interactions in Schizophrenia Pathogenesis.

Sumel Ashique, Radheshyam Pal, Anas Islam, Himanshu Sharma, Subhajit Mandal, Sanjesh Kumar, Mansi Singh, Samy Selim, Soad K Al Jaouni, Amisha Raikar and 3 more

Abstract readReview
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In one paragraph

Review in Current protein & peptide science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sumel AshiqueDepartment of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur 713212, West Bengal, India.
Radheshyam PalDepartment of Pharmaceutical Sciences, Bengal College of Pharmaceutical Sciences & Research, Durgapur 713212, West Bengal, India.
Anas IslamFaculty of Pharmacy, Integral University, Lucknow, 226026, Uttar Pradesh, India.
Himanshu SharmaDepartment of Pharmacy, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad (UP)-244001, India.ORCID 0000-0003-1122-3405
Subhajit MandalDepartment of Pharmaceutical Sciences, Faculty of Science and Engineering, Dibrugarh University, Dibrugarh 786004, Assam, India.
Sanjesh KumarResearch Scholar, Institute of Pharmaceutical Research, GLA University Mathura, U.P., India.
Mansi SinghResearch Scholar, Institute of Pharmaceutical Research, GLA University Mathura, U.P., India.
Samy SelimDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Al Jouf University, Sakakah 72388, Saudi Arabia.
Soad K Al JaouniDepartment of Hematology/Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Amisha RaikarDepartment of Pharmaceutics, PES Rajaram and Tarabai Bandekar College of Pharmacy, Ponda, Goa 403401, India.
Lavanya LakshminarayanaDepartment of Biochemistry, School of Allied Health Sciences, REVA University, Bengaluru-560064, India.
Bhavinee SharmaCollege of Pharmacy, JSS Academy of Technical Education, Noida, 201301, Uttar Pradesh, India.
Rashmi PathakDepartment of Pharmacy, Invertis University, Bareilly (UP)-243123, India.ORCID 0000-0001-9805-1719

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schizophrenia is now diagnosed mostly based on symptoms and physical signs rather than the patient's pathological and physiological markers. While oncologists once felt satisfied when their patients experienced a long remission, today, they are leading research into innovative treatments with molecularly targeted drugs, as well as strategies to enhance diagnostic accuracy and alleviate symptoms as the disease advances. Because biomarkers reflect an organism's physiological, physical, and biochemical state, they are very beneficial and have a wide range of real-- world uses. The identification of blood biomarkers may open up new avenues for studying schizophrenia. MicroRNAs (miRNAs) may serve as diagnostic indicators for schizophrenia as their abnormal expression has recently been linked to the disease's pathophysiology. The precise etiological process of schizophrenia remains largely unknown despite the general agreement that developmental and genetic factors play a critical role in the pathophysiology of the disorder. miRNAs have gained recognition as an essential post-transcriptional regulator in the regulation of gene expression in recent decades. The importance of miRNAs for brain development and neuroplasticity is well established.

Indexed as

MicroRNAsSchizophreniaAnimalsBiomarkersBrainGene Expression RegulationHumansBiomarkersMicroRNAsbiomarkersoxidative stress.peptidaseperipheral miRNAsproteinSchizophrenia

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.