Evidence map›Paper›PMID 40231997›Full record

ArticleCancer biology & medicine2025

Plasma

Mengyuan Wang, Zhouyi Yin, Hengmin Xu, Zongchao Liu, Sha Huang, Wenhui Wu, Yang Zhang, Tong Zhou, Weicheng You, Kaifeng Pan and 1 more

Abstract read
In one paragraph

Article in Cancer biology & medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mengyuan Wang *State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Zhouyi Yin *State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Hengmin XuState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Zongchao LiuState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Sha HuangState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Wenhui WuState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Yang ZhangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Tong ZhouKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Weicheng YouKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Kaifeng PanState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.ORCID 0000-0002-3680-3126
Wenqing LiState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing 100142, China.ORCID 0000-0002-8336-5552

Funding

Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support ZLRK202325Beijing Hospitals Authority's Ascent Plan DFL20241102China Postdoctoral Science Foundation 2024M760152National Natural Science Foundation of China 82273704Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0501400-2023ZD0501402Peking University Medicine Fund for World's Leading Discipline or Discipline Cluster Development BMU2022XKQ004Science Foundation of Peking University Cancer Hospital 2022-27Science Foundation of Peking University Cancer Hospital BJCH2024BJ02Science Foundation of Peking University Cancer Hospital BJCH2025CZ04Science Foundation of Peking University Cancer Hospital XKFZ2410
6 · The paper itself

Abstract

objectiveBased on multistage metabolomic profiling and Mendelian randomization analyses, the current study identified plasma metabolites that predicted the risk of developing gastric cancer (GC) and determined whether key metabolite levels modified the GC primary prevention effects.

methodsPlasma metabolites associated with GC risk were identified through a case-control study. Bi-directional two-sample Mendelian randomization analyses were performed to determine potential causal relationships utilizing the Shandong Intervention Trial (SIT), a nested case-control study of the Mass Intervention Trial in Linqu, Shandong province (MITS), China, the UK Biobank, and the FinnGen project.

resultsA higher genetic risk score for plasma

conclusionsElevated plasma

Indexed as

Aspartic AcidMetabolomicsStomach NeoplasmsAgedCase-Control StudiesChinaFemaleHumansMaleMendelian Randomization AnalysisMetabolomeMiddle AgedPolymorphism, Single NucleotidePrimary PreventionRisk FactorsAspartic AcidGastric cancerMendelian randomizationplasma metabolites

Identifiers

PMID40231997
PMCPMC12240189

What Socratic holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.