Evidence map›Paper›PMID 40232646›Full record

ArticleMolecular neurobiology2025

Daidzin Enhances the Anticonvulsion Effects of Carbamazepine and Diazepam, Possibly Through Voltage-Gated Sodium Channels and GABA

Muhammad Torequl Islam, Md Sakib Al Hasan, Jannatul Ferdous, Shoyaeb Ahammed, Md Shimul Bhuia, Salehin Sheikh, Noshin Tasnim Yana, Irfan Aamer Ansari, Siddique Akber Ansari, Md Saifuzzaman

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Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Muhammad Torequl IslamPharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh. dmt.islam@gstu.edu.bd.
Md Sakib Al HasanDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh.
Jannatul FerdousBioinformatics and Drug Innovation Laboratory, BioLuster Research Center Ltd, Gopalganj, 8100, Bangladesh.
Shoyaeb AhammedDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh.
Md Shimul BhuiaDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh.
Salehin SheikhDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh.
Noshin Tasnim YanaDepartment of Pharmacy, Gopalganj Science and Technology University, Gopalganj, 8100, Bangladesh.
Irfan Aamer AnsariDepartment of Drug Science and Technology, University of Turin, 10124, Turin, Italy.
Siddique Akber AnsariDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Md SaifuzzamanPharmacy Discipline, Khulna University, Khulna, 9208, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a neurological disorder characterized by recurrent seizures, affecting approximately 50 million people globally. Daidzin (DZN), a naturally occurring isoflavone, has shown various pharmacological effects, including neuroprotective activities in animals. This study investigated the anticonvulsant effects of DZN with possible mechanisms of action using behavioral studies using experimental animals and in silico approaches. For this, a pentylenetetrazole (PTZ, 80 mg/kg, i.p.)-induced seizure model was applied in young broiler chicks. Treatment groups included DZN (5, 10, 20 mg/kg, p.o.), carbamazepine (CAR: 80 mg/kg, p.o.), and diazepam (DZP: 5 mg/kg, p.o.) alone and in combinations. After PTZ administration, convulsion onset, frequency, duration, and mortality rates were recorded. We also performed an in vitro study to check GABAergic activity of DZN and DZP. Additionally, molecular docking studies were performed against the GABA

Indexed as

AnticonvulsantsCarbamazepineDiazepamReceptors, GABA-ASignal TransductionVoltage-Gated Sodium ChannelsAnimalsChickensDrug SynergismMaleMolecular Docking SimulationPentylenetetrazoleSeizuresAnticonvulsantsCarbamazepineDiazepamPentylenetetrazoleReceptors, GABA-AVoltage-Gated Sodium ChannelsAnticonvulsion effectDaidzinGABA receptor interactionVoltage-gated sodium channel

Identifiers

PMID40232646

What Socratic holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.