Evidence map›Paper›PMID 40233853›Full record

ArticleNeurobiology of disease2025

Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes.

Stephen J Paisey, Lucy R Jones, David J Harrison, Nicola J Drummond, Olivia Z Edwards, Maurice A Canham, Victoria H Roberton, Christopher Marshall, Greg Parker, Rachel Hills and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stephen J PaiseyWales Research and Diagnostic PET Imaging Centre, School of Medicine, Cardiff University, University Hospital Wales Main Building, Cardiff CF14 4XN, UK.
Lucy R JonesSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
David J HarrisonSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Nicola J DrummondCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK.
Olivia Z EdwardsSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Maurice A CanhamCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK.
Victoria H RobertonSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Christopher MarshallWales Research and Diagnostic PET Imaging Centre, School of Medicine, Cardiff University, University Hospital Wales Main Building, Cardiff CF14 4XN, UK.
Greg ParkerIndependent Imaging Consultant, Museum Avenue, Cardiff CF10 3AX, UK.
Rachel HillsSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Anne E RosserSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Emma L LaneSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VII Ave, Cardiff CF10 3NB, UK.
Stephen B DunnettSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK.
Tilo KunathCentre for Regenerative Medicine, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh EH16 4UU, UK; Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH16 4UU, UK.
Yaniv AssafSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK; School of Biochemistry Neurobiology Biophysics, Faculty of Life Sciences, Tel Aviv University, Israel.
Mariah J LelosSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AX, UK; Medicines Discovery Institute, Cardiff University, Cardiff, CF10 3AT, UK. Electronic address: lelosmj@cardiff.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell therapy is a promising therapeutic intervention for Parkinson's disease (PD) and is currently undergoing safety and efficacy testing in clinical trials worldwide. The goals of this project were (1) to determine whether [

Indexed as

BrainDopamineDopaminergic NeuronsRecovery of FunctionStem Cell TransplantationAnimalsDiffusion Magnetic Resonance ImagingDihydroxyphenylalanineHumansMaleOxidopaminePositron-Emission TomographyRatsRats, Sprague-DawleyDihydroxyphenylalanineDopaminefluorodopa F 18Oxidopamine

Identifiers

PMID40233853
PMCPMC7619129

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.