ArticleJournal of immunology (Baltimore, Md. : 1950)2025
Single-cell analysis of pig lung leukocytes and their response to influenza infection and oseltamivir therapy.
Article in Journal of immunology (Baltimore, Md. : 1950), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A single-cell atlas of porcine hematopoietic development.Nature communications · 2026Article
- Why pigs might help us develop better vaccines and drugs against influenza virus.Nature reviews. Immunology · 2026Article
- Pathogen-specific immune responses might underlie divergent outcomes of coronavirus and influenza infection in the natural porcine host.Communications biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Despite pigs being an important species in influenza A virus (IAV) epidemiology and a reliable preclinical model for human IAV infections, many aspects of the porcine pulmonary immune system remain poorly understood. Here, we characterized the single-cell landscape of lung leukocytes of healthy pigs and then compared them to pigs infected with 2009 pandemic H1N1 IAV with or without oseltamivir antiviral therapy. Our data show conserved features as well as species-specific differences in cell types and cell states compared with human and mouse lung lymphocytes. IAV infection induced a robust antiviral transcriptional response in multiple lymphoid and myeloid cell types, as well as distinct patterns of cell-cell crosstalk. Oseltamivir treatment substantially reduced these responses. Together, our findings describe key events in the pulmonary anti-IAV response of pigs that open new avenues to develop IAV vaccines and therapies. They should also enable the better use of pigs as a model for human IAV infection and immunity.
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Registered trials
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