ArticleJoint diseases and related surgery2025
Association of genetically predicted blood metabolites with osteopenia in individuals over 60 years of age: A Mendelian randomization study.
Article in Joint diseases and related surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly.Current osteoporosis reports · 2026Review
- Osteoporotic thoracolumbar vertebral compression fractures: Controversial issues and current solutions.Joint diseases and related surgery · 2026Article
- Causal associations of specific immunoglobulin G N-glycosylation subtypes with osteoporosis: A two-sample Mendelian randomization.Joint diseases and related surgery · 2026Article
- Exploring Causal Associations Between Plasma Metabolites and Sciatica: A Two-Sample Mendelian Randomization Analysis.Journal of pain research · 2026Article
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2 authors.
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Abstract
objectivesThis study aims to investigate the causal relationship between genetically predicted blood metabolites and osteoporotic fracture risk in individuals aged over 60 years, focusing on their role in bone metabolism and osteoporosis (OP). MATERIALS AND
methodsUsing Mendelian randomization (MR), we analyzed 1,400 blood metabolites selected for their involvement in metabolic and inflammatory pathways relevant to bone health. Bone mineral density (BMD) at the femoral neck served as a proxy for fracture risk, with reduced BMD defined as T-score ≤-1.0. Fourteen metabolites were associated with osteopenia, determined by T-score being lower than -1 at the femoral neck. The genome-wide association study (GWAS) data from the European Bioinformatics Institute (GCST005349) included 22,504 cases and 23.7 million SNPs from individuals of European ancestry aged ≥60 years. Genetic associations were evaluated using Inverse Variance Weighted (IVW), MR-Egger, and MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO) methods.
resultsAfter stringent screening, 14 metabolites were significantly associated with OP risk (p<0.05, false discovery rate [FDR] <0.2). The AMP-to-alanine ratio (odds ratio [OR]=0.900, 95% confidence interval [CI]: 0.845-0.958) was protective, while tauro-beta-muricholate (OR=0.855), glycosyl-N-stearoylsphingosine (OR=1.065), and the mannose-to-glycerol ratio (OR=1.116) increased risk. Sensitivity analyses confirmed robust results without heterogeneity or pleiotropy.
conclusionThis study identifies blood metabolites as potential causal markers for osteoporotic fracture risk, offering insights for risk assessment and prevention in the elderly.
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