ArticleQuantitative imaging in medicine and surgery2025
Impaired glymphatic system in patent foramen ovale based on diffusion tensor imaging analysis along the perivascular space.
Article in Quantitative imaging in medicine and surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Reduced choroid plexus volume aggravates the glymphatic system burden in patients with patent foramen ovale-related migraine with aura.Neuroradiology · 2026Article
- Association between glymphatic dysfunction and cryptogenic stroke risk in patients with patent foramen ovale: a retrospective cross-sectional study.Frontiers in neurology · 2025Article
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8 authors.
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Abstract
Background: Patent foramen ovale (PFO) is often complicated by cerebral diseases. Notably, PFO is disproportionately prevalent in cryptogenic stroke patients, but the mechanism of PFO is not clear yet. This study aimed to investigate whether there was a decline in the diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index that partially indicates interstitial fluid (ISF) dynamics and glymphatic system function in PFO patients, which had not been reported before, and to discuss the glymphatic metabolism mechanism by which PFO causes cryptogenic stroke. Methods: In total, 52 PFO patients and 50 age- and gender-matched healthy controls (HCs) who underwent diffusion tensor imaging (DTI) with magnetic resonance imaging (MRI) scanning were included in the study. Diffusivity maps in the x-axis (D Results: The PFO patients had significantly higher D Conclusions: The PFO patients showed a decrease in the DTI-ALPS index, which partly indicates ISF dynamic disorder and glymphatic system dysfunction, especially in dominant hemispheres. The DTI-ALPS index could serve as a neuroimaging biomarker for PFO. Further, the state of the impaired glymphatic system in PFO may increase the risk of stroke.
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