Evidence map›Paper›PMID 40235937›Full record

ArticleNon-coding RNA research2025

Lnc-RAINY regulates genes involved in radiation susceptibility through DNA:DNA:RNA triplex-forming interactions and has tumor therapeutic potential in lung cancers.

Emily S Westemeier-Rice, Michael T Winters, Travis W Rawson, Kiran J Patel, Olivia McHugh, Sierra Ward, Sarah McLaughlin, Amanda Stewart, Bishal Misra, Sebastian Dziadowicz and 4 more

Abstract read
In one paragraph

Article in Non-coding RNA research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Metamorphosis and lncRNAs: A Close Relationship.Genesis (New York, N.Y. : 2000) · 2026
    Review
  3. Noncoding RNAs in periodontitis: Progress and perspectives (Review).International journal of molecular medicine · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emily S Westemeier-RiceWest Virginia University Cancer Institute, West Virginia University, West Virginia, United States.
Michael T WintersDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, West Virginia, United States.
Travis W RawsonDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, West Virginia, United States.
Kiran J PatelWest Virginia School of Medicine, West Virginia University, West Virginia, United States.
Olivia McHughDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, West Virginia, United States.
Sierra WardDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, West Virginia, United States.
Sarah McLaughlinWest Virginia University Cancer Institute, West Virginia University, West Virginia, United States.
Amanda StewartWest Virginia University Cancer Institute, West Virginia University, West Virginia, United States.
Bishal MisraWest Virginia University School of Pharmacy, West Virginia University, West Virginia, United States.
Sebastian DziadowiczDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, West Virginia, United States.
Weijun YiDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, West Virginia, United States.
Sharan BobbalaWest Virginia University School of Pharmacy, West Virginia University, West Virginia, United States.
Gangqing HuDepartment of Microbiology, Immunology and Cell Biology, West Virginia University, West Virginia, United States.
Ivan MartinezWest Virginia University Cancer Institute, West Virginia University, West Virginia, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung cancer is the leading cause of cancer related deaths worldwide. Unfortunately, radiation resistance remains a major problem facing lung cancer patients. Recently, we identified a group of long non-coding RNAs (lncRNAs) known as linc-SPRY3 RNAs, expressed on the Y-chromosome, which play a role in radiation sensitivity by decreasing tumor burden

Indexed as

lncRNANSCLCSenescenceTherapeutic nanoparticlesY chromosome

Identifiers

PMID40235937
PMCPMC11999364

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.