ArticleBiochemistry and biophysics reports2025
Deciphering the association of cholesteryl ester transfer protein (CETP) gene polymorphisms with high-density lipoprotein cholesterol (HDL-c) levels in the Bangladeshi population.
Article in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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6 authors.
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Abstract
Cholesteryl ester transfer protein (CETP) gene polymorphisms influence CETP expression and high-density lipoprotein cholesterol (HDL-c) levels, yet their genetic impact remains unexplored in the Bangladeshi population, where low HDL-c is prevalent. This study examined the association of CETP -629C/A and 277C/T polymorphisms with circulating HDL-c levels in 402 individuals (217 males, 185 females). Serum lipid profiles were measured using an automated analyzer, and CETP polymorphisms were genotyped using PCR-RFLP. The -629C/A and 277C/T polymorphisms were in Hardy-Weinberg equilibrium, with heterozygous genotypes being the most frequent. While -629C/A genotypes showed no significant difference between the high and low HDL-c groups, individuals carrying the -629AA and CA + AA genotypes had significantly higher HDL-c levels compared to CC carriers (p = 0.023, p = 0.043). For the 277C/T, TT genotype differed significantly between the high and low HDL-c groups (p = 0.011, OR = 0.37) and, individuals carrying the 277 TT and CT + TT genotypes had significantly higher HDL-c compared to the CC genotype (p = 0.002, p = 0.019). Additionally, allelic analysis suggested a marginal association between the 277T allele and increased HDL-c levels (p = 0.051, OR = 0.59). Multiple regression analysis confirmed an inverse association between -629CC (β = -1.106, p = 0.038) and 277CC + CT (β = -0.963, p = 0.016) with HDL-c levels. However, no significant differences were observed in total cholesterol, triglycerides, LDL-c, or apolipoprotein levels across genotypes. These findings suggest that CETP -629CC, 277CC, and CT genotypes contribute to low HDL-c levels in the Bangladeshi population, highlighting the potential role of CETP genetic screening as a biomarker for identifying individuals at risk of HDL-c deficiency and associated cardiovascular complications.
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