Evidence map›Paper›PMID 40236431›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection.

Jay Preechanukul, Aljawharah Alrubayyi, Bo Sun, Edward Arbe-Barnes, Jonida Kokici, Frances Gorou, Sarun Prasitdumrong, Kelly A S da Costa, Natasha Fisher-Pearson, Noshin Hussain and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Jay PreechanukulDivision of Infection and Immunity, University College London, London, UK.
Aljawharah AlrubayyiNuffield Department of Clinical Neurosciences, University of Oxford, UK.
Bo SunNuffield Department of Clinical Medicine, University of Oxford, UK.
Edward Arbe-BarnesDivision of Infection and Immunity, University College London, London, UK.
Jonida KokiciDivision of Infection and Immunity, University College London, London, UK.
Frances GorouDivision of Infection and Immunity, University College London, London, UK.
Sarun PrasitdumrongDivision of Infection and Immunity, University College London, London, UK.
Kelly A S da CostaDivision of Infection and Immunity, University College London, London, UK.
Natasha Fisher-PearsonNuffield Department of Clinical Neurosciences, University of Oxford, UK.
Noshin HussainDivision of Infection and Immunity, University College London, London, UK.
Stephanie KucykowiczDivision of Infection and Immunity, University College London, London, UK.
Indrajit GhoshMortimer Market Centre, Department of HIV, CNWL NHS Trust, London, UK.
Fiona BurnsThe Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, UK.
Sabine KinlochThe Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, UK.
Pedro SimoesThe Ian Charleson Day Centre, Royal Free Hospital NHS Foundation Trust, UK.
Sanjay BhaganiDivision of Infection and Immunity, University College London, London, UK.
Patrick T F KennedyBarts Liver Centre, Barts & The London School of Medicine & Dentistry, QMUL, UK.
Mala K MainiDivision of Infection and Immunity, University College London, London, UK.
Rachael Bashford-RogersDepartment of Biochemistry, University of Oxford, UK.
Upkar S GillBarts Liver Centre, Barts & The London School of Medicine & Dentistry, QMUL, UK.
Dimitra PeppaDivision of Infection and Immunity, University College London, London, UK.ORCID 0000-0002-9281-5471

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Chronic HBV infection disproportionately affects people living with HIV, who are often excluded from functional cure studies. This study investigates CD8 Design: We analysed CD8 Results: Transcriptomic analysis revealed a distinct signature in co-infection, with upregulation of genes associated with TCR signaling, inhibitory pathways and progenitor-exhausted markers ( Conclusion: Our findings demonstrate that individuals with well-controlled HBV/HIV co-infection maintain more robust CD8

Identifiers

PMID40236431
PMCPMC11998845

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.