ReviewBiological trace element research2025
Zinc as a Modulator of Male Fertility: Interplay Between Lipid Metabolism, Oxidative Stress, and Sperm Function.
Review in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Acute Dietary Zinc Deficiency Impairs Sperm Motility but Not Gonadal mRNA Methylation in Mice.Molecular reproduction and development · 2026Article
- Metals/Metalloids Profile in Seminal Plasma/Serum of Patients with Asthenozoospermia/Oligozoospermia: Correlation with Semen Quality.Biological trace element research · 2026Article
- Mendelian Randomization Analysis Reveals Iron as a Potential Contributor to Male Infertility.The world journal of men's health · 2026Article
- Zinc oxide nanoparticles supplementation improve the quality and lipid profiles of frozen boar semen.Frontiers in veterinary science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility is a multifaceted and pressing global health challenge, with male reproductive impairment playing a significant role in its overall burden. Zinc (Zn), a biologically indispensable trace element, is fundamental to spermatogenesis and overall male reproductive function. This narrative review explores the following aspects: (1) the mechanistic function of Zn in spermatogenesis, (2) the impact of oxidative stress on Zn status and male infertility, (3) the interplay between Zn and lipid metabolism in male reproductive physiology, (4) the relationship between Zn concentrations and semen parameters, and (5) the effects of Zn supplementation on sperm quality, alongside relevant institutional recommendations. The molecular pathways underlying Zn deficiency-induced enzymatic dysfunction, oxidative stress, and lipid homeostasis disruption remain partially elucidated, warranting further investigation into their interdependent effects on male infertility. While accumulating evidence suggests that Zn supplementation may have therapeutic potential in male infertility management, guidelines for its clinical application vary considerably across institutions and regions. To establish a clear and evidence-based framework for the function of Zn in male reproductive health, future research should prioritize determining of optimal Zn levels, the mechanistic links between Zn and lipid metabolism, and the long-term clinical outcomes of Zn supplementation in infertile populations.
Indexed as
Identifiers
40237945What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.