Involvement of purinergic signalling in the vasomotor response to hypochlorous acid in porcine coronary artery.

Ashwaq Baghdadi, William R Dunn, Vera Ralevic

Abstract read

In one paragraph

Article in Purinergic signalling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Lipoprotein(a)/CD36 Interaction Drives IL-6/RhoA-GTP Signaling and miRNA Epigenetic Regulation in Coronary Artery Spasm.Pharmaceuticals (Basel, Switzerland) · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ashwaq BaghdadiSchool of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

William R DunnSchool of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK.

Vera RalevicSchool of Life Sciences, Queen's Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK. Vera.ralevic@nottingham.ac.uk.ORCID 0000-0002-5252-280X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypochlorous acid (HOCl) is generated by neutrophils during the innate immune response. ATP is released from cells by various stimuli and during inflammation but whether ATP is released by and participates in the response to HOCl is unclear. This study investigated vasomotor effects of HOCl on the porcine coronary artery (PCA) and the involvement of ATP and purine receptors. HOCl at 100 μM induced rapid and transient endothelium-dependent relaxation followed by slow and sustained endothelium-independent relaxation. Transient endothelium-dependent relaxation was induced by 500 μM HOCl, followed by endothelium-dependent contraction, then slow endothelium-independent relaxation. 8-(p-sulphophenyl)theophylline (8-SPT), an adenosine/P1 receptor antagonist, blocked rapid relaxation and contraction to HOCl but an A

Indexed as

Coronary VesselsHypochlorous AcidReceptors, PurinergicSignal TransductionVasomotor SystemAdenosine TriphosphateAnimalsEndothelium, VascularSwineVasodilationAdenosine TriphosphateHypochlorous AcidReceptors, PurinergicAdenosine receptorATPCoronary arteryHypochlorous acidInflammationP2 receptor

Identifiers

PMID40238052

DOI10.1007/s11302-025-10086-7

PMCPMC12595199

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.