Evidence mapPaperPMID 40238306Full record

ArticleInternational journal of environmental research and public health2025

Homozygous AA Genotype of IL-17A and 14-bp Insertion Polymorphism in HLA-G 3'UTR Are Associated with Increased Risk of Gestational Diabetes Mellitus.

Amaxsell Thiago Barros de Souza, Cecília Rodrigues Lucas, Kleyton Thiago Costa de Carvalho, Antonia Pereira Rosa Neta, Emanuelly Bernardes-Oliveira, Juliana Dantas de Araújo Santos Camargo, André Ducati Luchessi, Ricardo Ney Cobucci, Janaina Cristiana de Oliveira Crispim

Abstract read
In one paragraph

Article in International journal of environmental research and public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amaxsell Thiago Barros de SouzaPostgraduate Program in Sciences Applied to Women's Health, Federal University of Rio Grande do Norte, Natal 59012-310, Brazil.ORCID 0000-0002-7085-8788
Cecília Rodrigues LucasFaculty of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
Kleyton Thiago Costa de CarvalhoDepartment of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0000-0003-2650-4365
Antonia Pereira Rosa NetaPostgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0009-0001-9194-0502
Emanuelly Bernardes-OliveiraPostgraduate Program in Development and Technological Innovation in Medicines, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
Juliana Dantas de Araújo Santos CamargoPostgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0000-0001-8692-5706
André Ducati LuchessiDepartment of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.ORCID 0000-0002-2758-8102
Ricardo Ney CobucciPostgraduate Program in Sciences Applied to Women's Health, Federal University of Rio Grande do Norte, Natal 59012-310, Brazil.ORCID 0000-0002-0184-2061
Janaina Cristiana de Oliveira CrispimPostgraduate Program in Sciences Applied to Women's Health, Federal University of Rio Grande do Norte, Natal 59012-310, Brazil.ORCID 0000-0002-1344-0078

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 001
6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is a common pregnancy complication characterized by hyperglycemia and insulin resistance, with unclear genetic mechanisms. The specific involvement of proinflammatory cytokines, including IL-17A, and the immuno-tolerogenic HLA-G remains poorly understood in GDM. We aimed to explore the associations of three polymorphisms,

Indexed as

Diabetes, GestationalHLA-G AntigensInterleukin-173' Untranslated RegionsAdultBrazilCase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHomozygoteHumansINDEL MutationPolymorphism, GeneticPolymorphism, Single NucleotidePregnancy3' Untranslated RegionsHLA-G AntigensIL17A protein, humanInterleukin-17genetic associationGestational Diabetes MellitusHLA-G 14-bp insertion/deletionIL-17A polymorphismIL-17RA polymorphism

Identifiers

PMID40238306
PMCPMC11941881

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.