ArticleThe Plant cell2025
SIZ1 SUMOylates and stabilizes WRI1 to safeguard seed filling and fatty acid biosynthesis under high-temperature stress.
Article in The Plant cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- From wrinkled seeds to plant oil accumulation networks: the legacy of a Plant Physiology classic.Plant physiology · 2026Review
- SUMOylation in plants: A versatile post-translational mechanism responding to environmental stresses.Journal of integrative plant biology · 2026Review
- How wheat SIZes the day under pathogen attack.The Plant cell · 2026Article
- SIZ1-mediated SUMOylation of HAT1 enhances plant thermotolerance in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Genome-Wide Association Study Uncovers Candidate Genes Governing Oil Quality Traits in Sunflower (Plants (Basel, Switzerland) · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
High-temperature stress hinders seed filling, reducing seed quality and crop yield. However, the molecular mechanisms underlying this process remain unclear. Here, we identify SAP AND MIZ1 DOMAIN-CONTAINING LIGASE1 (SIZ1) as a key regulator of seed filling under prolonged high temperatures in Arabidopsis (Arabidopsis thaliana). SIZ1 and WRINKLED1 (WRI1) are co-expressed during seed filling, and overexpressing either gene enhances seed filling and promotes fatty acid biosynthesis under high-temperature stress. Genetic and biochemical analyses revealed that SIZ1 stabilizes WRI1 by promoting its SUMOylation at Lys-257 and Lys-266, thereby inhibiting its interaction with the CULLIN3-based ubiquitin E3 ligase adaptor protein BTB/POZMATH (BPM) and preventing its ubiquitination and degradation. Mutating these SUMOylation sites accelerates WRI1 degradation, impairing its function in seed filling under high-temperature stress. Furthermore, high-temperature stress induces SIZ1 expression and reduces WRI1 levels, suggesting that SIZ1-mediated SUMOylation counteracts high-temperature stress-induced WRI1 instability. These findings establish SIZ1 as a crucial factor in maintaining WRI1 stability and seed filling under high-temperature stress, providing valuable genetic resources and a theoretical foundation for addressing prolonged high-temperature stress in agricultural production.
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