Evidence map›Paper›PMID 40239812›Full record

ArticleJournal of thrombosis and haemostasis : JTH2025

Risk factors for venous thrombosis after discharge from medical hospitalizations: the Medical Inpatient Thrombosis and Hemostasis study.

Ryan M Thomas, Andrew D Sparks, Katherine Wilkinson, Mansour Gergi, Allen B Repp, Nicholas S Roetker, Nicholas L Smith, Preetika Muthukrishnan, Karlyn Martin, Neil A Zakai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Haemostasis and the Need for Antithrombotics: An Introduction.Handbook of experimental pharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryan M ThomasDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA. Electronic address: ryan.thomas@uvmhealth.org.
Andrew D SparksDepartment of Medical Biostatistics, Biomedical Statistics Research Core, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Katherine WilkinsonDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Mansour GergiDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA.
Allen B ReppDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA.
Nicholas S RoetkerChronic Disease Research Group, Hennepin Healthcare Research Institute, Minneapolis, Minnesota, USA.
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, Washington, USA; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle Washington, USA; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle Washington, USA.
Preetika MuthukrishnanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA.
Karlyn MartinDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA.
Neil A ZakaiDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA; Division of Hematology/Oncology, University of Vermont Medical Center, Burlington, Vermont, USA; Department of Pathology, Laboratory Medicine, Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.

Funding

Thrombosis and Bleeding Risk Assessment in Medical InpatientsR01HL141290 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI Deirdra R Terrell, Neil Adrian Zakai · 2019 to 2026
$3.5M
NHLBI NIH HHS R01 HL141290
6 · The paper itself

Abstract

backgroundMany studies on hospital-associated venous thromboembolism (VTE) do not specifically assess the risk factors for events after discharge.

objectivesThis study aimed to identify risk factors for postdischarge venous thromboembolism (PD-VTE) after a medical hospitalization.

methodsPatients discharged from a medical hospitalization at the University of Vermont Medical Center between January 2010 and September 2019 were followed up for inpatient and outpatient VTE events for up to 90 days. Age-adjusted, sex-adjusted, race-adjusted, and length of stay-adjusted Cox models estimated the hazard ratios (HR) and 95% CIs for potential risk factors for PD-VTE.

resultsAmong 22 599 admissions, there were 180 PD-VTE events (90-day cumulative incidence of 0.8%). The median time from discharge to PD-VTE was 29 days. Of previously identified in-hospital VTE risk factors, only history of VTE (HR, 3.34; 95% CI, 2.26-4.93) and active cancer (HR, 3.13; 95% CI, 2.31-4.23) were associated with increased risk of PD-VTE. Compared to <2-day hospital stays, longer hospital stays (HR, 1.84; 95% CI, 1.23-2.75, for 6-10 days and HR, 1.64; 95% CI, 0.93, 2.90, for 11+ days) were associated with increased risk of PD-VTE. Both mortality (HR, 1.22; 95% CI, 1.06-1.41 per SD higher) and readmission (HR, 1.30; 95% CI, 1.13-1.50, per SD higher) Elixhauser comorbidity indices were associated with increased risk of PD-VTE.

conclusionsRisk factors for VTE after discharge from medical hospitalization differ from risk factors for in-hospital VTE. These data support that characteristics of the hospitalization influence PD-VTE risk, and if indicated, PD-VTE risk should be assessed at discharge.

Indexed as

HemostasisPatient DischargeVenous ThromboembolismVenous ThrombosisAdultAgedAged, 80 and overFemaleHospitalizationHumansIncidenceInpatientsLength of StayMaleMiddle AgedRisk Assessmentcomorbiditylength of stayoutpatientspatient dischargevenous thromboembolism

Identifiers

PMID40239812
PMCPMC13221839

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.