Evidence map›Paper›PMID 40240294›Full record

ReviewJournal of molecular cell biology2025

Beyond the ends: potential implications of telomeric repeat-containing RNA (TERRA) for CNS diseases.

Hadjer Namous, Raghu Vemuganti

Abstract readReview
In one paragraph

Review in Journal of molecular cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hadjer NamousDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA.ORCID 0000-0003-3325-7534
Raghu VemugantiDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA.

Funding

Role of RNAs in post-stroke brain damageR35NS132184 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Raghu VEMUGANTI · 2023 to 2026
$4.1M
Epitranscriptomic regulation by m6A RNA methylation after strokeR01NS130763 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI VEMUGANTI, RAGHU · 2023 to 2023
$618k
BLRD VA I01 BX005127BLRD VA I01 BX006062BLRD VA IK6 BX005690Department of Neurological SurgeryNIH HHS R35 NS132184NIH HHS RO1 NS130763NINDS NIH HHS R01 NS130763NINDS NIH HHS R35 NS132184University of WisconsinU.S. Department of Veterans Affairs I01 BX006062U.S. Department of Veterans Affairs IK6BX005690
6 · The paper itself

Abstract

Telomeric repeat-containing RNA (TERRA) is a class of non-coding RNAs emanating from telomeres and controlling telomere dynamics. Recent studies showed that TERRAs influence chromatin structure and gene expression. TERRAs can also play a crucial role in controlling inflammation, oxidative stress, DNA damage, and cellular senescence. This review discusses the significance of TERRAs in modulating these processes, particularly in the central nervous system (CNS). While our understanding of TERRAs largely stems from cancer research, their involvement in these physiologic and pathologic pathways highlights their potential as therapeutic targets for CNS disorders as well.

Indexed as

Central Nervous System DiseasesRNA, Long NoncodingTelomereAnimalsCellular SenescenceDNA DamageHumansOxidative StressRNA, Long Noncodingbrain damageCNS dysfunctionnon-coding RNAtelomeretranscription

Identifiers

PMID40240294
PMCPMC12720274

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.