ArticleNature communications2025
A wheat CC-NBS-LRR protein Ym1 confers WYMV resistance by recognizing viral coat protein.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Dynamics of resistant genes and their relationship to resistance to wheat yellow mosaic disease in Japanese wheat germplasms.Breeding science · 2026Article
- Comparative Analysis of Rhizosphere Bacteria ofPolish journal of microbiology · 2026Article
- Structural diversity of Ym2, a gene conferring resistance against Wheat yellow mosaic virus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Characterization of three quantitative trait loci conferring robust resistance to wheat yellow mosaic virus in the wheat cultivar Shunyou.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Ym1 is the most widely utilized gene for wheat yellow mosaic virus (WYMV) disease control in worldwide wheat breeding. Here, we successfully isolated the responsible gene for Ym1. It encodes a typical CC-NBS-LRR type R protein, which is specifically expressed in root and induced upon WYMV infection. Ym1-mediated WYMV resistance is likely achieved by blocking viral transmission from the root cortex into steles, thereby preventing systemic movement to aerial tissues. Ym1 CC domain is essential for triggering cell death. Ym1 specifically interacts with WYMV coat protein, and this interaction leads to nucleocytoplasmic redistribution, a process for transitioning Ym1 from an auto-inhibited to an activated state. The activation subsequently elicits hypersensitive responses and establishes WYMV resistance. Ym1 is likely introgressed from the sub-genome X
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.