Evidence map›Paper›PMID 40240650›Full record

SynthesisNature plants2025

Re-analysis of mobile mRNA datasets raises questions about the extent of long-distance mRNA communication.

Pirita Paajanen, Melissa Tomkins, Franziska Hoerbst, Ruth Veevers, Michelle Heeney, Hannah Rae Thomas, Federico Apelt, Eleftheria Saplaoura, Saurabh Gupta, Margaret Frank and 5 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Go with the Phloem: A Review of the Methods to Collect Plant Phloem Tissue.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  9. Review
  10. Review
  11. Genome Editing by Grafting.International journal of molecular sciences · 2025
    Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pirita Paajanen *Computational and Systems Biology, John Innes Centre, Norwich, UK. Pirita.Paajanen@jic.ac.uk.ORCID 0000-0002-0561-3717
Melissa Tomkins *Computational and Systems Biology, John Innes Centre, Norwich, UK.ORCID 0000-0002-1593-5023
Franziska Hoerbst *Computational and Systems Biology, John Innes Centre, Norwich, UK.ORCID 0000-0002-1288-7732
Ruth VeeversComputational and Systems Biology, John Innes Centre, Norwich, UK.ORCID 0000-0001-7599-5725
Michelle HeeneySchool of Integrative Plant Science, Cornell University, Ithaca, NY, USA.ORCID 0000-0001-6734-0219
Hannah Rae ThomasCell and Developmental Biology, John Innes Centre, Norwich, UK.ORCID 0000-0001-5538-2331
Federico ApeltDepartment II, Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.ORCID 0000-0003-3450-9369
Eleftheria SaplaouraDepartment II, Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.ORCID 0000-0002-3463-2589
Saurabh GuptaDepartment II, Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.ORCID 0000-0002-5984-852X
Margaret FrankSchool of Integrative Plant Science, Cornell University, Ithaca, NY, USA.ORCID 0000-0002-8269-8240
Dirk WaltherDepartment II, Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.ORCID 0000-0002-5755-9265
Christine FaulknerCell and Developmental Biology, John Innes Centre, Norwich, UK.ORCID 0000-0003-3905-8077
Julia KehrDepartment of Biology, Institute for Plant Sciences and Microbiology, University of Hamburg, Hamburg, Germany.ORCID 0000-0003-3617-9981
Friedrich KraglerDepartment II, Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany.ORCID 0000-0001-5308-2976
Richard J MorrisComputational and Systems Biology, John Innes Centre, Norwich, UK. Richard.Morris@jic.ac.uk.ORCID 0000-0003-3080-2613

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 433194101EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 810131National Science Foundation (NSF) DBI-2019674National Science Foundation (NSF) DGE-2139899National Science Foundation (NSF) IOS-1942437RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X010996/1, BB/X007685/1, BB/X016056/1 and BB/Y008782/1.RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/X01102X/1
6 · The paper itself

Abstract

Short-read RNA-seq studies of grafted plants have led to the proposal that thousands of messenger RNAs (mRNAs) move over long distances between plant tissues

Indexed as

PlantsRNA, MessengerRNA, PlantRNA, MessengerRNA, Plant

Identifiers

PMID40240650
PMCPMC12095074

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.