Evidence map›Paper›PMID 40240774›Full record

ArticleScientific reports2025

Glucosamine induces hepatic FGF21 expression by activating the Akt/mTOR/p70S6K axis and driving PGC-1α activity.

Shui-Yu Liu, Luen-Kui Chen, Pin-Hsuan Li, Guan-Lin Wu, Tsung-Hui Wu, Yuan-Bin Yu, Heng-Fu Lin, Chi-Chang Juan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shui-Yu LiuInstitutes of Physiology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou District, Taipei, 112304, Taiwan.
Luen-Kui ChenInstitutes of Physiology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou District, Taipei, 112304, Taiwan.
Pin-Hsuan LiInstitutes of Physiology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou District, Taipei, 112304, Taiwan.
Guan-Lin WuInstitutes of Physiology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou District, Taipei, 112304, Taiwan.
Tsung-Hui WuInstitutes of Physiology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou District, Taipei, 112304, Taiwan.
Yuan-Bin Yu *Division of Oncology and Hematology, Department of Internal Medicine, Far-Eastern Memorial Hospital, No. 21, Sec. 2, Nanya S. Rd., Banqiao District, New Taipei City, 220216, Taiwan. fishie.yu@gmail.com.
Heng-Fu Lin *Division of Trauma, Department of Surgery, Far-Eastern Memorial Hospital, No. 21, Sec. 2, Nanya S. Rd., Banqiao District, New Taipei City, 220216, Taiwan. hengfu57@gmail.com.
Chi-Chang Juan *Institutes of Physiology, College of Medicine, National Yang Ming Chiao Tung University, No. 155, Sec. 2, Linong St., Beitou District, Taipei, 112304, Taiwan. ccjuan@nycu.edu.tw.

Funding

Far-Eastern Memorial Hospital FEMH-NYCU 107DN05
6 · The paper itself

Abstract

Glucosamine (GlcN) is a common supplement used to alleviate osteoarthritis, but it may dysregulate glucose tolerance and induce insulin resistance, thereby increasing metabolic burden. The liver is a vital organ that modulates the Akt/mTOR/p70S6K signaling pathway in response to growth and metabolism. Fibroblast growth factor 21 (FGF21) is a hepatokine involved in regulating glucose and lipid metabolism. Additionally, increased circulating FGF21 levels have been linked to the prediction of metabolic disorders and type 2 diabetes. However, the regulatory mechanism controlling FGF21 expression by GlcN remains unclear. In the present study, GlcN stimulation led to several outcomes, including an increase in cell content, secretion, and mRNA and protein levels of FGF21 in hepatocytes. Moreover, inhibition of the Akt/mTOR/p70S6K axis resulted in reduced FGF21 expression in response to GlcN. Importantly, GlcN-mediated expression of FGF21 relies on PGC-1α upregulation. These results suggest that GlcN increases FGF21 expression through the activation between Akt/mTOR/p70S6K pathway and PGC-1α dependent manner.

Indexed as

Fibroblast Growth FactorsGlucosamineLiverPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProto-Oncogene Proteins c-aktRibosomal Protein S6 Kinases, 70-kDaTOR Serine-Threonine KinasesAnimalsGene Expression RegulationHepatocytesHumansMiceSignal Transductionfibroblast growth factor 21Fibroblast Growth FactorsGlucosaminePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaProto-Oncogene Proteins c-aktRibosomal Protein S6 Kinases, 70-kDaTOR Serine-Threonine KinasesDiabetesFGF21GlucosamineHepatocytePGC-1α

Identifiers

PMID40240774
PMCPMC12003878

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.