Evidence map›Paper›PMID 40241264›Full record

Trial reportSleep2025

Effects of time-restricted eating on actigraphy-derived sleep parameters: post hoc analysis of a randomized, isocaloric feeding study.

Daisy Duan, Luu V Pham, Jonathan C Jun, Ruth-Alma Turkson-Ocran, Scott J Pilla, Jeanne M Clark, Nisa M Maruthur

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03527368 (The Time-Restricted Intake of Meals Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03527368 nacompletednot on this map

The Time-Restricted Intake of Meals Study: A Randomized, Controlled Feeding Study

TypeinterventionalSponsorJohns Hopkins UniversityRan2018 to 2019Enrolled41ConditionsPreDiabetes, ObesityArmsTime-restricted feeding, Usual feeding pattern
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daisy DuanDivision of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-4392-3206
Luu V PhamDivision of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-1944-6315
Jonathan C JunDivision of Pulmonary and Critical Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-5788-3535
Ruth-Alma Turkson-OcranDivision of General Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Scott J PillaDivision of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jeanne M ClarkDepartment of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Nisa M MaruthurDivision of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

Metabolic Effects of Circadian-Based Dinner TimeK23DK133690 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$199k
Impact of Nocturnal Hypoxemia on Glucose during Sleep in High Altitude Sleep Disordered BreathingK23HL155730 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$196k
American Heart Association 17SFRN33590069 and 17SFRN33560006NHLBI NIH HHS K23 HL155730NIDDK NIH HHS K23 DK133690
6 · The paper itself

Abstract

STUDY

objectivesTime-restricted eating (TRE) is a novel dietary intervention targeting weight loss and cardiometabolic risk factors. The impact of TRE on sleep patterns remains under-explored.

methodsThis was a post hoc analysis of a parallel-arm, controlled feeding trial in 41 adults with obesity and prediabetes/diabetes, randomized to TRE (08:00 am-06:00 pm) or usual eating pattern (UEP; 08:00 am-12:00 am) for 12 weeks. We objectively determined sleep-wake patterns from 7-day wrist actigraphy data obtained at baseline and week 12. From this data, we derived total sleep time (TST) and sleep midpoint over a 24-hour period, sleep onset/offset, and sleep continuity measures. We used paired t-tests or Wilcoxon signed rank tests to compare data between baseline and week 12 within intervention arms and Mann-Whitney U tests or Wilcoxon signed rank tests to compare changes between intervention arms.

results38 participants (20 UEP; 18 TRE; 93% of those randomized in the parent trial) with adequate actigraphy data (mean age 59.6 ± 7.3 years, 92% female, 92% Black, mean BMI 36.3 ± 4.7 kg/m2) were analyzed. Compared to UEP, TRE increased TST by 55 minutes (p = .03). TRE shifted sleep midpoint to 44 minutes earlier, from 03:24 am to 02:40 am (p = .01), while UEP maintained the same sleep midpoint at 03:15 am. Sleep onset shifted from a median of 12:22 am to 11:52 pm in TRE (p = .03) while it remained stable in UEP (p = .97). There were no differences in sleep offset and sleep continuity within and between intervention arms.

conclusionsTRE increased sleep time and caused earlier sleep onset compared to UEP, revealing how the timing of eating may affect sleep timing and duration. CLINICAL TRIAL: The Time Restricted Intake of Meals Study (TRIM). URL: https://clinicaltrials.gov/study/NCT03527368?tab=history&a=4. REGISTRATION: NCT03527368.

Indexed as

ActigraphyFastingObesitySleepAdultFemaleHumansMaleMiddle AgedTime Factorsobesitysleep durationtime-restricted eating

Identifiers

PMID40241264
PMCPMC12663717

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.