ArticleAnimal bioscience2025
Combined transcriptome and metabolome analysis of chicken follicles in Tengchong Snow Chicken follicle selection.
Article in Animal bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Dietary Chlorogenic Acid-Rich Green Coffee Bean Extract Improves Laying Performance and Antioxidant Status in Heat-Stressed Laying Hens.Animals : an open access journal from MDPI · 2026Article
- Integrated metabolomic and transcriptomic analyses reveal that glutamine promotes chicken primordial germ cell‑like cell specification potentially through α-ketoglutarate.Animal bioscience · 2026Article
- Effects of dihydroorotate dehydrogenase inhibition and vitamin E supplementation on ferroptosis-related mechanisms and post-mortem meat quality in broiler chickens.Animal bioscience · 2026Article
- Nanopore long-read RNA sequencing reveals key genes regulating pre-hierarchical follicle development in the chicken ovary.Poultry science · 2026Article
- Integrated ATAC-seq and mRNA-seq analyses on granulosa cells identify key regulators of follicle selection in chickens.Journal of animal science and biotechnology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectiveThe development of pre-hierarchical follicles (PHFs), especially small yellow follicles (SYFs), directly affects the recruitment of dominant follicles and subsequently affects the egg-laying performance of chickens. The development of PHFs, especially SYFs, and their regulatory mechanisms remain unclear.
methodsTranscriptomic and metabolomic analyses were conducted on large white follicles (LWFs) and SYFs in chickens.
resultsTranscriptome sequencing revealed 258 differentially expressed genes (DEGs) between SYFs and LWFs, with 172 genes upregulated and 86 downregulated. The DEGs were mapped to 17 Kyoto encyclopedia of genes and genomes (KEGG) pathways, including glutathione metabolism, ferroptosis, calcium signaling pathway, and neuroactive ligand- receptor interactions, among others. The metabolome analysis revealed 129 significant differential metabolites (DMs), comprising 36 upregulated and 93 downregulated metabolites. The DMs were associated with nine KEGG pathways, including glutathione metabolism, alpha-linolenic acid metabolism, and linoleic acid metabolism, etc. The combined transcriptional and metabolic analysis revealed significantly enriched pathways. Five KEGG pathways associated with follicular development were identified, including glutathione metabolism, ferroptosis, alpha-linolenic acid metabolism, linoleic acid metabolism, and pyrimidine metabolism.
conclusionGlutathione metabolism may directly inhibit Ferroptosis, which can induce apoptosis of granulosa cells, thereby regulating SYFs development in chickens. These findings could serve as a reference for improving the egg-laying performance of Tengchong snow chickens.
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