Evidence map›Paper›PMID 40241920›Full record

ArticleClinical parkinsonism & related disorders2025

Anti-dipeptidyl-peptidase-like protein-6 (DPPX) autoimmune encephalitis associated with severe multifocal dystonia.

Eric Roddy, Erik Gentry, Victoria Holiday, David Robertson, Peter Hedera

Abstract readCase Reports
In one paragraph

Article in Clinical parkinsonism & related disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Eric RoddyUniversity of Louisville School of Medicine, Department of Neurology, USA.
Erik GentryUniversity of Louisville School of Medicine, Department of Neurology, USA.
Victoria HolidayUniversity of Louisville School of Medicine, Department of Neurology, USA.
David RobertsonNorton Neuroscience Institute, Department of Neurology, University of Louisville, 220, Abraham Flexner Way, Suite 606, USA.
Peter HederaUniversity of Louisville School of Medicine, Department of Neurology, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anti-DPPX encephalitis is a rare form of autoimmune encephalitis characterized antibodies against a subunit of Kv4.2 potassium channels. Characteristic clinical features include cognitive dysfunction, parasomnias, psychosis, and seizures. Motor symptoms typically include myoclonus, tremor, and midline ataxia. DPPX encephalitis presenting as new-onset focal dystonia has not been previously described.

Indexed as

Autoimmune encephalitisDPPXDystoniaImmunotherapyToxin therapy

Identifiers

PMID40241920
PMCPMC12002181

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.