ArticleInternational journal of nanomedicine2025
Zeolitic Imidazolate Framework-90 Treats Fungal Keratitis by Promoting Macrophage Apoptosis and Targeting Increased Mitochondrial Reactive Oxygen Species in Aspergillus Fumigatus.
Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- From fields to eyes: the epidemiology and immune challenges of fungal keratitis.Frontiers in cellular and infection microbiology · 2026Article
- Pathogen-induced mitochondrial dysfunction: mechanistic insights, immune crosstalk, and therapeutic opportunities.Frontiers in cellular and infection microbiology · 2025Review
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Authors and funding
9 authors.
Funding
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Abstract
Background: Fungal keratitis is a severe vision-threatening corneal infection with a prognosis influenced by fungal virulence and the host's immune defense mechanisms. However, there is still a lack of effective drugs that attenuate fungal virulence while relieving the inflammatory response caused by fungal keratitis. Purpose: Finding an effective treatment to solve these problems is particularly important. Methods: We synthesized Zeolitic imidazolate framework-90 (ZIF-90) by water-based synthesis method and characterized it. In vitro experiments included mycelium electron microscopy, Cell Counting Kit-8 (CCK-8), and Enzyme-linked immunosorbent assay (ELISA). These trials verified the disruptive effects of ZIF-90 on morphology, cell membrane, cell wall, and biofilm formation of Aspergillus fumigatus ( Results: ZIF-90 has therapeutic effects on fungal keratitis, which could break the protective organelles of
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