Ribosylation-induced increase in advanced glycation end products has limited impacts on mechanical properties in human cortical bone.

Katelynn R Gallagher, Olivia N White, Andrew A Tomaschke, Dyann M Segvich, Joseph M Wallace

Abstract read

In one paragraph

Article in Bone reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Diabetic bone fragility through advanced glycation end product-collagen axis: Mechanisms and therapy of sodium glucose cotransporter 2 inhibitors.World journal of diabetes · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Katelynn R GallagherWeldon School of Biomedical Engineering, Department of Purdue University, 723 W Michigan St (SL220), Indianapolis, IN, USA 46202.

Olivia N WhiteWeldon School of Biomedical Engineering, Department of Purdue University, 723 W Michigan St (SL220), Indianapolis, IN, USA 46202.

Andrew A TomaschkeWeldon School of Biomedical Engineering, Department of Purdue University, 723 W Michigan St (SL220), Indianapolis, IN, USA 46202.

Dyann M SegvichWeldon School of Biomedical Engineering, Department of Purdue University, 723 W Michigan St (SL220), Indianapolis, IN, USA 46202.

Joseph M WallaceWeldon School of Biomedical Engineering, Department of Purdue University, 723 W Michigan St (SL220), Indianapolis, IN, USA 46202.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes affects over 38 million individuals in the U.S. and is associated with a heightened risk of fractures despite normal or elevated bone mineral density (BMD). This increased fracture susceptibility may be linked to the accumulation of advanced glycation end products (AGEs), which are theorized to compromise bone quality by stiffening the collagen network, leading to tissue embrittlement. In this study, the mechanical effects of AGE accumulation in human cortical bone were evaluated

Indexed as

DiabetesDynamic mechanical analysisFluorescenceMicrocomputed tomographyRibose/ribosylation

Identifiers

PMID40242611

DOI10.1016/j.bonr.2025.101841

PMCPMC12002958

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.