Who was studied, and how
Two numbers in the abstract
Where each one falls
Where it lands on the map
What it changes
Among 4 other studies
3,234people with type 2 diabetes, in this paper
The trial randomly assignedassigned by chance
metformin (850 mg twice daily)
blinded placebo
No clear effect on total cancer cases−10%
randomisedThe trial randomly assignedassigned by chance
intensive lifestyle (ILS) intervention
blinded placebo
No clear effect on total cancer cases−4%
randomisedthe abstract, start to end
… and placebo, respectively, with a HR of 0.90 (95% confidence interval, 0.73-1.10) for metformin compared with placebo and 0.96 (95% confidence interval, …
← favours treatmentfavours comparator →
could be chanceTotal cancer incidencemetformin (850 mg twice daily) vs blinded placebo
HR 0.900.73–1.10
Total cancer incidenceintensive lifestyle (ILS) intervention vs blinded placebo
HR 0.960.79–1.18
MetforminDiet, exercise & lifestyleAdverse events & safety
Diet, exercise & lifestyle × adverse events & safetyharms?no deciding trial
unlikelylikely
0.25only evidence
Metformin × adverse events & safetyharms?mixed
unlikelylikely
0.270.27 without it
← favours treatmentfavours comparator →
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