Evidence map›Paper›PMID 40243413›Full record

ArticleInternational journal of molecular sciences2025

Down-Regulation of HLA-C Expression on Melanocytes May Contribute to the Therapeutic Efficacy of UVB Phototherapy in Psoriasis.

Yukiyasu Arakawa, Akiko Arakawa, Seçil Vural, Mengwen He, Sigrid Vollmer, Jörg C Prinz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yukiyasu ArakawaDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University Munich, D-80337 Munich, Germany.ORCID 0000-0003-4249-6393
Akiko ArakawaDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University Munich, D-80337 Munich, Germany.ORCID 0000-0002-6679-3029
Seçil VuralDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University Munich, D-80337 Munich, Germany.ORCID 0000-0001-6561-196X
Mengwen HeDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University Munich, D-80337 Munich, Germany.ORCID 0000-0002-1891-6506
Sigrid VollmerDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University Munich, D-80337 Munich, Germany.
Jörg C PrinzDepartment of Dermatology and Allergy, University Hospital, Ludwig-Maximilian-University Munich, D-80337 Munich, Germany.ORCID 0000-0002-8857-5495

Funding

German Research Foundation PR 241/5-1 and 5-2Japan Society for the Promotion of Science grant 21K16234
6 · The paper itself

Abstract

UVB phototherapy effectively treats psoriasis. Although it suppresses both innate and adaptive immunity, it remains unclear why UVB irradiation is primarily effective for T-cell-mediated but not inflammatory skin diseases of other etiologies. Using a Vα3S1/Vβ13S1 T-cell receptor (TCR) from a lesional psoriatic CD8

Indexed as

Down-RegulationHLA-C AntigensMelanocytesPsoriasisUltraviolet TherapyHumansInterferon-gammaMicroRNAsReceptors, Antigen, T-CellUltraviolet RaysHLA-C AntigensInterferon-gammaMicroRNAsReceptors, Antigen, T-CellHLA-C*06:02HLA-class I expressionmelanocyte immunogenicitypsoriasisUVB phototherapy

Identifiers

PMID40243413
PMCPMC11988605

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.