Evidence map›Paper›PMID 40243451›Full record

ArticleInternational journal of molecular sciences2025

Inhibitory Potential of Boscalid and Abamectin Towards Acetylcholinesterase and Butyrylcholinesterase: Computational and In Vitro Studies.

Biljana Arsić, Stefan Petrović, Budimir S Ilić, Milka Vrecl, Tomaž Trobec, Kristina Sepčić, Robert Frangež, Sanja M Glišić, Jelena S Milićević

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Biljana ArsićDepartment of Chemistry, Faculty of Sciences and Mathematics, University of Niš, 18000 Niš, Serbia.ORCID 0000-0002-1248-5864
Stefan PetrovićDepartment of Chemistry, Faculty of Sciences and Mathematics, University of Niš, 18000 Niš, Serbia.ORCID 0000-0001-6528-2756
Budimir S IlićDepartment of Chemistry, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.ORCID 0000-0002-2808-3501
Milka VreclInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-9968-9228
Tomaž TrobecInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0003-0806-8694
Kristina SepčićDepartment of Biology, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-4023-5379
Robert FrangežInstitute of Preclinical Sciences, Veterinary Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID 0000-0002-0636-9277
Sanja M GlišićDepartment for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-5691-1055
Jelena S MilićevićDepartment for Bioinformatics and Computational Chemistry, Institute of Nuclear Sciences, University of Belgrade, 11000 Belgrade, Serbia.ORCID 0000-0001-7783-6218

Funding

Ministry of Education, Science and Technological Development of the Republic of Serbia 337-00-21/2020-09/19Ministry of Science, Technological Development and Innovations of the Republic of Serbia contract numbers 451-03-47/2023-01/200124 and 451-03-66/2024-03/200124 (B. Arsić, S. Petrović), and 451-03-47/2023-01/200017 and 451-03-66/2024-03/200017 (S. M. Glišić, J. S. Milićević)Slovenian Research and innovation Agency research programs P4-0053 and P1-0207
6 · The paper itself

Abstract

The growing demand for agricultural products has led to the misuse of pesticides, resulting in the use of higher concentrations of these substances. This has led to an increase in toxicity imposed on other beneficial organisms and to the bioaccumulation of toxic pesticide concentrations in the bodies of both pests and non-target organisms, as well as in their end users, including humans. In this study, the neurotoxic potential of the commonly used pesticides abamectin (an insecticide) and boscalid (a fungicide) was evaluated. Both in vitro and in silico studies showed that human butyrylcholinesterase is not a target for abamectins B1A and B1B. Boscalid showed a modest Glide score (-28.8 kJ/mol) and a considerably higher IC

Indexed as

AcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsIvermectinNiacinamideHumansMolecular Docking SimulationMolecular Dynamics SimulationabamectinAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsIvermectinNiacinamideADMETcholinesteraseelectron-ion interaction potentialenzyme inhibitionmolecular dockingmolecular dynamics simulationspesticides

Identifiers

PMID40243451
PMCPMC11988634

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.