ArticleInternational journal of molecular sciences2025
Role of Adiponectin in Regulating Cytokines and Its Contribution to the Occurrence and Progression of Clinical Mastitis in Holstein Cows.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Knockout of theVeterinary sciences · 2026Article
- Ruminal dysbiosis-induced mastitis: new insight into the pathogenesis of mastitis.Journal of animal science and biotechnology · 2025Review
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Authors and funding
12 authors.
Funding
Abstract
Cytokines are crucial in various physiological and pathological processes, especially in inflammatory diseases in mammals. However, the comprehensive identification of cytokines and their potential regulatory functions in the mammary glands of Holstein cows suffering from clinical mastitis (CM) remains only partially understood. This study aimed to systematically identify biological processes (BPs) and differentially expressed proteins (DEPs) associated with cytokines and to explore their functions through the analysis of previously obtained data from data-independent acquisition (DIA) proteomics. We confirmed that the dynamic balance between pro- and anti-inflammatory factors is closely associated with dairy mastitis. A total of 4 BPs, comprising 75 upregulated and 16 downregulated DEPs, were identified, particularly in relation to adiponectin (ADIPOQ), which strongly interacts with the other DEPs and participates in peroxisome proliferator-activated receptor (PPAR) and adipocytokine signaling pathways. Immunohistochemical and immunofluorescence staining revealed that ADIPOQ was predominantly localized in the cytoplasm of mammary epithelial cells. Moreover, the expression levels of
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