ReviewInternational journal of molecular sciences2025
Chronic Stress-Associated Depressive Disorders: The Impact of HPA Axis Dysregulation and Neuroinflammation on the Hippocampus-A Mini Review.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
What it found
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Who cites it
114 citing papers in PubMed.
- Mental health profiles and resilience among medical students in an active conflict zone: a cluster analysis.Medical education online · 2026Article
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- Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026Review
- Stress, needs, and behaviour: understanding chronic stress in pet domestic dogs (Canis lupus familiaris) from the prism of needs.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Sleep disturbances as early indicators of incident psychiatric disease.European archives of psychiatry and clinical neuroscience · 2026Article
- Adaptogenic-Like Potential of Bauhinia forficata Leaf Extracts: Behavioral and Oxidative Outcomes in an Acute Stress Mouse Model.Brain and behavior · 2026Article
- Association between atherogenic index of plasma and depression in patients with type 2 diabetes mellitus: A cross-sectional study.Medicine · 2026Article
- Stress and Parkinson's disease: from dysfunctional detection to impaired handling: a narrative review.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- A Longitudinal Quasi-Experimental Evaluation of a Cognitive-Behavioral Intervention in Teachers: Changes in Psychosocial Risks, Burnout, Depression, and Salivary Cortisol.Behavioral sciences (Basel, Switzerland) · 2026Article
- Hyperforin as a Multifunctional Specialized Metabolite of Natural Origin for Chronic Diseases: From Molecular Mechanisms to Clinical Translation.Current issues in molecular biology · 2026Review
- Depression and Risk of Delirium in Older Adults: A Retrospective Cohort Study Using German Primary Care Data.Geriatrics (Basel, Switzerland) · 2026Article
- Psycho-cardiovascular interaction network in cardiovascular health and disease: signaling pathways and molecular mechanisms.Precision clinical medicine · 2026Review
- The association of multi-system health status and its longitudinal changes with cardiovascular disease risk: insights from a secondary analysis of four multinational cohort studies.Journal of global health · 2026Article
- PMiScience · 2026Review
- Risk Factors for Postoperative Sleep Disturbance in Elderly Patients Undergoing Hip Arthroplasty Surgery: The Role of Preoperative Depression and Anxiety.Actas espanolas de psiquiatria · 2026Article
- Sex-specific circadian and behavioral phenotypes in aged growth hormone receptor knockout mice.GeroScience · 2026Article
- Sociodemographic Characteristics and Dietary Habits Associated with Generalized Anxiety Disorder Symptoms in Adults Living in the Kingdom of Saudi Arabia: A Large Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- From Biomarkers to New Treatments for Post-Traumatic Stress Disorder.Neuroscience bulletin · 2026Review
- Overactive Bladder and Suicidal Ideation: A National Cross-Sectional Study Identifying Depression as the Primary Mediator.Neurourology and urodynamics · 2026Article
- Integrated biomarkers of oxidative stress NLRP3 inflammasome and kynurenine pathway reflect disease severity and diagnostic discrimination in depression.Scientific reports · 2026Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic stress significantly contributes to the development of depressive disorders, with the hypothalamic-pituitary-adrenal (HPA) axis playing a central role in mediating stress responses. This review examines the neurobiological alterations in the hippocampus linked to HPA axis dysregulation in chronic stress-associated depressive disorders. The prolonged activation of the HPA axis disrupts cortisol regulation, leading to the decline of both physical and mental health. The chronic stress-induced HPA axis dysfunction interacts with inflammatory pathways and generates oxidative stress, contributing to cellular damage and neuroinflammation that further aggravates depressive symptoms. These processes result in structural and functional alterations in the hippocampus, which is essential for emotional regulation and cognitive function. Comprehending the impact of chronic stress on the HPA axis and associated neurobiological pathways is essential for formulating effective interventions for depressive disorders. This review summarises the existing findings and underscores the necessity for future investigations into intervention strategies to improve physical and psychological wellbeing targeting at HPA axis dysregulation for the betterment of psychological wellbeing and human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.