Evidence map›Paper›PMID 40243663›Full record

ArticleInternational journal of molecular sciences2025

Control of Conformational Transitions by the Conserved GX

Xintong Zhang, Yanhong Xu, Qingyang Chen, Chan Li, Yuan-Wei Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xintong ZhangSchool of Life Sciences, Guangzhou University, Guangzhou 510006, China.
Yanhong XuSchool of Life Sciences, Guangzhou University, Guangzhou 510006, China.
Qingyang ChenSchool of Life Sciences, Guangzhou University, Guangzhou 510006, China.
Chan LiSchool of Life Sciences, Guangzhou University, Guangzhou 510006, China.
Yuan-Wei ZhangSchool of Life Sciences, Guangzhou University, Guangzhou 510006, China.ORCID 0000-0002-4276-9251

Funding

National Natural Science Foundation of China 32071233National Natural Science Foundation of China 32371304
6 · The paper itself

Abstract

The neurotransmitter sodium symporters (NSSs) play critical roles in the neurotransmission of monoamine and amino acid neurotransmitters and are the molecular targets of therapeutic agents in the treatment of several psychiatric disorders. Despite significant progress in characterizing structures and transport mechanisms, the management of conformational transitions by structural elements coupled with ion and substrate binding remains to be fully understood. In the present study, we biochemically identified a conserved GX

Indexed as

Serotonin Plasma Membrane Transport ProteinsAmino Acid MotifsAmino Acid SequenceAnimalsConserved SequenceHumansModels, MolecularMutationProtein ConformationProtein DomainsSerotonin Plasma Membrane Transport Proteinsconformational transitionGX9P motifneurotransmitter sodium symporterserotonin transporterTM5 unwindingtransport mechanism

Identifiers

PMID40243663
PMCPMC11988846

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.