Evidence map›Paper›PMID 40243865›Full record

ArticleMemorias do Instituto Oswaldo Cruz2025

Leukocyte telomere length and telomerase activity in Long COVID patients from Rio de Janeiro, Brazil.

Giane Gonçalves Dos Reis, Rafaele Tavares Silvestre, Gilda Alves, Lucas Delmonico, Mariana Chantre-Justino, Aline Dos Santos Moreira, Beatriz de Lima Alessio Müller, Carolina Ramos do Nascimento, Denzel Luis Pereira da Silva, Louisy Sanches Dos Santos and 2 more

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In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giane Gonçalves Dos ReisUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Laboratório de Marcadores Circulantes, Rio de Janeiro, RJ, Brasil.
Rafaele Tavares SilvestreUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Laboratório de Marcadores Circulantes, Rio de Janeiro, RJ, Brasil.
Gilda AlvesUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Laboratório de Marcadores Circulantes, Rio de Janeiro, RJ, Brasil.ORCID http://orcid.org/0000-0003-2246-719X
Lucas DelmonicoUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Laboratório de Marcadores Circulantes, Rio de Janeiro, RJ, Brasil.
Mariana Chantre-JustinoUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Laboratório de Marcadores Circulantes, Rio de Janeiro, RJ, Brasil.
Aline Dos Santos MoreiraFundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Genômica Aplicada e Bioinovações, Rio de Janeiro, RJ, Brasil.
Beatriz de Lima Alessio MüllerFundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Genômica Aplicada e Bioinovações, Rio de Janeiro, RJ, Brasil.
Carolina Ramos do NascimentoUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Laboratório de Marcadores Circulantes, Rio de Janeiro, RJ, Brasil.
Denzel Luis Pereira da SilvaUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Laboratório de Marcadores Circulantes, Rio de Janeiro, RJ, Brasil.
Louisy Sanches Dos SantosUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Microbiologia, Imunologia e Parasitologia, Rio de Janeiro, RJ, Brasil.
Ana Luíza de Mattos-GuaraldiUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Departamento de Microbiologia, Imunologia e Parasitologia, Rio de Janeiro, RJ, Brasil.
Maria Helena OrnellasUniversidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas, Laboratório de Marcadores Circulantes, Rio de Janeiro, RJ, Brasil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCoronavirus disease 2019 (COVID-19) is caused by the new coronavirus 2 (severe acute respiratory syndrome coronavirus 2 - SARS-CoV-2). Long COVID is a new condition associated with persistent COVID-19 symptoms and/or new emerging symptoms. Telomeres are specialised structures for genome protection at the end of chromosomes and telomerase is the enzyme that synthesises telomere DNA.

objectivesPatients with Long COVID symptoms were recruited at the Pedro Ernesto University Hospital (HUPE) in Rio de Janeiro, Brazil, with the main purpose of investigating the association between telomere length and Long COVID.

methodsLeukocyte telomere length (LTL) was determined by quantitative real-time polymerase chain reaction (qPCR) in 34 Long COVID patients compared to a control group (n = 122). Telomerase activity was determined by qPCR assays using the commercial kit from ScienCell. A questionnaire on symptoms, vaccine doses and blood count was completed.

findingsThe Long COVID patients were found to have an increase in LTL. Telomerase activity was also examined in a smaller number of patients and found to be reactivated in the blood. MAIN

conclusionsIt will be necessary to conduct further studies and monitor Long COVID patients to determine if future health issues could be linked to telomerase activity and elongated telomeres.

Indexed as

COVID-19LeukocytesTelomeraseTelomereAdultAgedBrazilCase-Control StudiesFemaleHumansMaleMiddle AgedReal-Time Polymerase Chain ReactionSARS-CoV-2Telomerase

Identifiers

PMID40243865
PMCPMC11984962

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.